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Very high and very low levels of preoperative absolute monocyte count indicate poor long-term survival outcomes in patients with pancreatic adenocarcinoma. A preliminary study
, 1, 1
Affiliations- Department of General and Transplant Surgery, Medical University of Lodz, Lodz, Poland
open access
Abstract
Introduction.We aimed to assess the prognostic significance of preoperative absolute monocyte count (AMC) in baseline peripheral blood samples among pancreatic cancer (PC) patients as possible manifest signs of non-optimal immunity status.
Material and methods.PC patients who underwent palliative surgical treatment without earlier chemo- or radio-therapy (n = 59).
Results.Median AMC was comparable in each subgroup, showing no significant differences. We have adopted an arbitrary trichotomic AMC division: low (<0.4 G/l, n = 9), medium (>0.4 and ≤0.6 G/l, n = 36) and high (>0.6 G/l, n = 14). Optimal (medium AMC) and non-optimal (both low and high AMC) was independent and a statistically significant predictor of OS. Resectability and optimal AMC constituted best Cox proportional hazard model, being equivalent predictors of OS.
Conclusions.Baseline AMC status may be an independent predictor of OS in this group of patients. Further research is needed to explain the biological nature of this phenomenon more widely.
Abstract
Introduction.We aimed to assess the prognostic significance of preoperative absolute monocyte count (AMC) in baseline peripheral blood samples among pancreatic cancer (PC) patients as possible manifest signs of non-optimal immunity status.
Material and methods.PC patients who underwent palliative surgical treatment without earlier chemo- or radio-therapy (n = 59).
Results.Median AMC was comparable in each subgroup, showing no significant differences. We have adopted an arbitrary trichotomic AMC division: low (<0.4 G/l, n = 9), medium (>0.4 and ≤0.6 G/l, n = 36) and high (>0.6 G/l, n = 14). Optimal (medium AMC) and non-optimal (both low and high AMC) was independent and a statistically significant predictor of OS. Resectability and optimal AMC constituted best Cox proportional hazard model, being equivalent predictors of OS.
Conclusions.Baseline AMC status may be an independent predictor of OS in this group of patients. Further research is needed to explain the biological nature of this phenomenon more widely.
Keywords
pancreatic cancer; immune system; monocytes; lymphocyte-to-monocyte ratio (LMR); monocyte-tolymphocyte ratio (MLR)
About this articleTitle
Very high and very low levels of preoperative absolute monocyte count indicate poor long-term survival outcomes in patients with pancreatic adenocarcinoma. A preliminary study
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
282-287
Published online
2022-08-22
Page views
3675
Article views/downloads
333
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2022;72(5):282-287.
Keywords
pancreatic cancer
immune system
monocytes
lymphocyte-to-monocyte ratio (LMR)
monocyte-tolymphocyte ratio (MLR)
Authors
Alicja Majos
Adam Durczyński
Janusz Strzelczyk
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