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Principles of prevention and management of adverse events of immunomodulatory drugs in treatment of multiple myeloma

Grzegorz Charliński1, David H. Vesole23, Artur Jurczyszyn4
DOI: 10.5603/NJO.a2022.0031
Affiliations
  1. Department of Hematology, Medical Faculty, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
  2. Department of Hematology/Oncology, Medstar Georgetown University Hospital, Washington, United States
  3. John Theurer Cancer Center at Hackensack Meridian School of Medicine, Hackensack, United States
  4. Plasma Cell Dyscrasias Center, Department of Hematology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland

open access

Ahead of print
Review article
Published online: 2022-05-25

Abstract

Over the past 15 years, significant progress has been made in the understanding the biology and treatment of multiple myeloma (MM). This is due to the introduction of new therapies and new applications of known drugs associated with a better understanding of how to optimize treatment to patient and disease characteristics. Indeed, 15 new drugs have been approved over this time period. Immunomodulatory drugs (IMiDs) have been used in the treatment of MM for over 20 years. Initially, it was thalidomide, then its analogues lenalidomide and pomalidomide. And, in the future, cereblon E3 ligase modulators CelMoDs, such as iberdomide and CC-480. Currently, IMiDs are mainly used as the backbone of multi-drug protocols, including in combination with monoclonal antibodies and proteasome inhibitors. Given the common utilization of IMiDs in the management of MM, it is relevant to review the safety profile of IMiDs and the management of adverse events (AEs).

Abstract

Over the past 15 years, significant progress has been made in the understanding the biology and treatment of multiple myeloma (MM). This is due to the introduction of new therapies and new applications of known drugs associated with a better understanding of how to optimize treatment to patient and disease characteristics. Indeed, 15 new drugs have been approved over this time period. Immunomodulatory drugs (IMiDs) have been used in the treatment of MM for over 20 years. Initially, it was thalidomide, then its analogues lenalidomide and pomalidomide. And, in the future, cereblon E3 ligase modulators CelMoDs, such as iberdomide and CC-480. Currently, IMiDs are mainly used as the backbone of multi-drug protocols, including in combination with monoclonal antibodies and proteasome inhibitors. Given the common utilization of IMiDs in the management of MM, it is relevant to review the safety profile of IMiDs and the management of adverse events (AEs).

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Keywords

adverse events; immunomodulatory drugs; lenalidomide; management; multiple myeloma; pomalidomide; thalidomide; treatment

About this article
Title

Principles of prevention and management of adverse events of immunomodulatory drugs in treatment of multiple myeloma

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Review paper

Published online

2022-05-25

Page views

27

Article views/downloads

33

DOI

10.5603/NJO.a2022.0031

Keywords

adverse events
immunomodulatory drugs
lenalidomide
management
multiple myeloma
pomalidomide
thalidomide
treatment

Authors

Grzegorz Charliński
David H. Vesole
Artur Jurczyszyn

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