open access

Vol 71, No 6 (2021)
Research paper (original)
Published online: 2021-10-15
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Hilar cholangiocarcinoma – the long-term results of radical and palliative treatment

Włodzimierz Otto1, Janusz Sierdziński2, Justyna Smaga1, Krzysztof Dudek1, Krzysztof Zieniewicz1
·
Nowotwory. Journal of Oncology 2021;71(6):348-356.
Affiliations
  1. Departament of General, Transplant and Liver Surgery, University Medical Center, Medical University of Warsaw, Warsaw, Poland
  2. Departament of Medical Informatics and Telemedicine, University Medical Center, Medical University of Warsaw, Warsaw, Poland

open access

Vol 71, No 6 (2021)
Original article
Published online: 2021-10-15

Abstract

Introduction. Hilar cholangiocarcinoma (HC) is a tumor that requires a multidisciplinary approach and treatment. The 3- and 5-year survival rates of HC patients treated with surgery and palliative methods were evaluated in the study.

Material and methods. The study covered 368 patients treated between 2000–2014. Of them, 137 patients were ca­tegorized for surgery (RT group), and 231 for palliative treatment (PT group). The overall 3- and 5-year survival rates were determined by the log-rank test. The Cox hazard regression model revealed the relative prognostic factors.

Results. The 3- and 5-year survival rates accounted for 38% and 21% after surgery, but 13% and 0 after palliative treatment (p < 0.0001). Radical tumor resection, negative lymph nodes, and early tumor T stage were the factors conducive to survival.

Conclusions.  Surgery, if the radical tumor resection is possible, offers a chance for long-term survival. The effects of surgical treatment are of little consequence in the face of poor treatment outcomes of palliative patients, however.

Abstract

Introduction. Hilar cholangiocarcinoma (HC) is a tumor that requires a multidisciplinary approach and treatment. The 3- and 5-year survival rates of HC patients treated with surgery and palliative methods were evaluated in the study.

Material and methods. The study covered 368 patients treated between 2000–2014. Of them, 137 patients were ca­tegorized for surgery (RT group), and 231 for palliative treatment (PT group). The overall 3- and 5-year survival rates were determined by the log-rank test. The Cox hazard regression model revealed the relative prognostic factors.

Results. The 3- and 5-year survival rates accounted for 38% and 21% after surgery, but 13% and 0 after palliative treatment (p < 0.0001). Radical tumor resection, negative lymph nodes, and early tumor T stage were the factors conducive to survival.

Conclusions.  Surgery, if the radical tumor resection is possible, offers a chance for long-term survival. The effects of surgical treatment are of little consequence in the face of poor treatment outcomes of palliative patients, however.

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Keywords

hilar cholangiocarcinoma; Bismuth-Corlette typing; T-stage typing; hemihepatectomy; negative resection margin

About this article
Title

Hilar cholangiocarcinoma – the long-term results of radical and palliative treatment

Journal

Nowotwory. Journal of Oncology

Issue

Vol 71, No 6 (2021)

Article type

Research paper (original)

Pages

348-356

Published online

2021-10-15

Page views

6026

Article views/downloads

505

DOI

10.5603/NJO.a2021.0063

Bibliographic record

Nowotwory. Journal of Oncology 2021;71(6):348-356.

Keywords

hilar cholangiocarcinoma
Bismuth-Corlette typing
T-stage typing
hemihepatectomy
negative resection margin

Authors

Włodzimierz Otto
Janusz Sierdziński
Justyna Smaga
Krzysztof Dudek
Krzysztof Zieniewicz

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