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Individually personalized radiotherapy vs. evidence (trials) based standards – paradigms and dilemmas
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Affiliations- Div. Research Programmes, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
- Wroclaw Comprehensive Cancer Centre, Wroclaw, Poland
- Department of Oncology, Wroclaw Medical University, Wroclaw, Poland
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Abstract
This paper opens up to discussion whether some questions, points of view, and doubts counterbalance the belief and dogmas that randomized clinical trials (mainly in radiotherapy) should be considered as the only source of guidelines to design novel therapeutic standards in radiotherapy. A number of the physics, radiotherapy, clinical radiobiology and genetic and molecular tumor’s characteristics suggest that radiotherapy protocols based on the “evidence based trials” seem to be antonymous to individually personalized therapy. The major goal of this paper is to consider and discuss whether individually personalized radiotherapy is already attainable and reliable or still remains the exception.
Abstract
This paper opens up to discussion whether some questions, points of view, and doubts counterbalance the belief and dogmas that randomized clinical trials (mainly in radiotherapy) should be considered as the only source of guidelines to design novel therapeutic standards in radiotherapy. A number of the physics, radiotherapy, clinical radiobiology and genetic and molecular tumor’s characteristics suggest that radiotherapy protocols based on the “evidence based trials” seem to be antonymous to individually personalized therapy. The major goal of this paper is to consider and discuss whether individually personalized radiotherapy is already attainable and reliable or still remains the exception.
Keywords
physical vs. biological doses; randomized trials; personalized radiotherapy; caveat emptor
About this articleTitle
Individually personalized radiotherapy vs. evidence (trials) based standards – paradigms and dilemmas
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
296-302
Published online
2021-08-20
Page views
6112
Article views/downloads
391
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2021;71(5):296-302.
Keywords
physical vs. biological doses
randomized trials
personalized radiotherapy
caveat emptor
Authors
Bogusław Maciejewski
Adam Maciejczyk
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