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Research paper (original)
Published online: 2021-08-20
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Resection margins do not influence survival in vulvar cancer: treatment results in patients with long-term follow-up

Szymon Piątek, Wojciech Michalski, Mariusz Bidziński, Anna Dańska-Bidzińska
DOI: 10.5603/NJO.a2021.0048

open access

Ahead of print
Original article
Published online: 2021-08-20

Abstract

Introduction. The main purpose of the study was to assess margin resection as prognostic factor of vulvar cancer in patients with long term follow-up.

Materials and methods. The study included 84 vulvar cancer patients who underwent radical  treatment: surgery (n = 84), radiotherapy (n = 16), chemoradiotherapy (n = 5). Clinicopathological factors regarding survival and recurrence were analyzed. Median follow-up was 74 months.

Results. Resection margins were not related to PFS (p = 0.93) and OS (p = 0.84). On multivariate analysis, maximum tumor size >25 mm (p = 0.026) and inguinal lymph nodes involvement (p = 0.028) were factors influencing risk of death. The risk of recurrence was related to tumor dimension >25 mm (p = 0.011), but not to inguinal node metastasis (p = 0.086).

Discussion. Inadequate surgical margin would be salvaged by adjuvant treatment.

Conclusions. Maximum tumor dimension >25 mm and metastases in the inguinal lymph nodes are independent prognostic factors for the survival of patients with vulvar cancer.

Abstract

Introduction. The main purpose of the study was to assess margin resection as prognostic factor of vulvar cancer in patients with long term follow-up.

Materials and methods. The study included 84 vulvar cancer patients who underwent radical  treatment: surgery (n = 84), radiotherapy (n = 16), chemoradiotherapy (n = 5). Clinicopathological factors regarding survival and recurrence were analyzed. Median follow-up was 74 months.

Results. Resection margins were not related to PFS (p = 0.93) and OS (p = 0.84). On multivariate analysis, maximum tumor size >25 mm (p = 0.026) and inguinal lymph nodes involvement (p = 0.028) were factors influencing risk of death. The risk of recurrence was related to tumor dimension >25 mm (p = 0.011), but not to inguinal node metastasis (p = 0.086).

Discussion. Inadequate surgical margin would be salvaged by adjuvant treatment.

Conclusions. Maximum tumor dimension >25 mm and metastases in the inguinal lymph nodes are independent prognostic factors for the survival of patients with vulvar cancer.

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Keywords

vulva; cancer; prognosis; neoplasm recurrence

About this article
Title

Resection margins do not influence survival in vulvar cancer: treatment results in patients with long-term follow-up

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Research paper (original)

Published online

2021-08-20

DOI

10.5603/NJO.a2021.0048

Keywords

vulva
cancer
prognosis
neoplasm recurrence

Authors

Szymon Piątek
Wojciech Michalski
Mariusz Bidziński
Anna Dańska-Bidzińska

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