Introduction Skin-sparing or nipple-sparing mastectomy is a method of surgical treatment that is increasingly used in the treatment of patients with breast cancer. More often women themselves decide or even ask to undergo this type of surgery. In our paper, we present the issue of combined treatment of sixty-two patients after nipple-sparing or skin-sparing mastectomy with a positive sentinel lymph node. Realization of this type of surgery has further consequences in adjuvant treatment policies. Material and Methods The group of previously untreated 62 women with positive sentinel lymph node was entered into this analysis. The individual plan of treatment was established for every patient by the multidisciplinary team according to the rules of a breast cancer unit. All patients were treated in the Holycross Cancer Centre in 2015-2018. Results The early results show that proper qualification and realization of oncological treatment is safe and effective, and severe complications not very often appeared. Conclusions Skin-sparing or nipple-sparing mastectomy is a method of surgical treatment that is increasingly used in the treatment of patients with breast cancer. It should be remembered that the qualification for this type of procedure should be careful and adjuvant treatment should be rationally planned. Our experience shows that it is an effective and safe method.