open access

Ahead of print
Research paper (original)
Published online: 2021-02-08
Get Citation

Impact volumetric status of neck lymph nodes on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer

Marcin Miszczyk, Bogusław Maciejewski, Magdalena Markowska
DOI: 10.5603/NJO.a2021.0014

open access

Ahead of print
Original article
Published online: 2021-02-08

Abstract

The study analyses an impact of volumetric nodal involvement (Total Nodal Volume – TNV) on Local Control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer. The results show significant decrease of the LTC (within a constant GTV) by about 10 – 20%, when the TNV increases from 10 cm3 to 40 cm3. It suggests delivery an extra boost dose of 3 – 4 extra fractions of 2.0 Gy fractions to the primary tumour in case of nodal involvement (initial Total Nodal Volume).

Abstract

The study analyses an impact of volumetric nodal involvement (Total Nodal Volume – TNV) on Local Control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer. The results show significant decrease of the LTC (within a constant GTV) by about 10 – 20%, when the TNV increases from 10 cm3 to 40 cm3. It suggests delivery an extra boost dose of 3 – 4 extra fractions of 2.0 Gy fractions to the primary tumour in case of nodal involvement (initial Total Nodal Volume).

Get Citation

Keywords

Total Nodal Volume; Local Tumour Control; extra boost dose

About this article
Title

Impact volumetric status of neck lymph nodes on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Research paper (original)

Published online

2021-02-08

DOI

10.5603/NJO.a2021.0014

Keywords

Total Nodal Volume
Local Tumour Control
extra boost dose

Authors

Marcin Miszczyk
Bogusław Maciejewski
Magdalena Markowska

References (16)
  1. Brenner DJ. Dose, volume, and tumor-control predictions in radiotherapy. Int J Radiat Oncol Biol Phys. 1993; 26(1): 171–179.
  2. Peters LJ, Wendt CD. Tumor volume as a predictor of radiocurability--a drop in the bucket? Int J Radiat Oncol Biol Phys. 1990; 19(2): 497–498.
  3. Mukherji SK, Schmalfuss IM, Castelijns J, et al. Clinical applications of tumor volume measurements for predicting outcome in patients with squamous cell carcinoma of the upper aerodigestive tract. AJNR Am J Neuroradiol. 2004; 25(8): 1425–1432.
  4. Plataniotis GA, Theofanopoulou ME, Kalogera-Fountzila A, et al. Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial. Int J Radiat Oncol Biol Phys. 2004; 59(4): 1018–1026.
  5. Studer G, Lütolf UM, El-Bassiouni M, et al. Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT. Acta Oncol. 2007; 46(3): 386–394.
  6. Been MJ, Watkins J, Manz RM, et al. Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 2008; 118(8): 1377–1382.
  7. Knegjens JL, Hauptmann M, Pameijer FA, et al. Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer. Head Neck. 2011; 33(3): 375–382.
  8. Studer G, Rordorf T, Glanzmann C. Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer. Radiat Oncol. 2011; 6: 120.
  9. Fowler JF. Practical Time-Dose evaluation, or how to stop working and learn to love Linear Quadratics. In: Lewitt S, Purdy J, Perez C, Poortmans p. ed. Technical Basis of radiation therapy. Practical clinical applications. Heidelberg Springer, Berlin 2012: 3–31.
  10. Mc Br, Withers HR. Biological basis of radiation therapy. In: Perez and Brady’s Principle and Practice of Radiation Oncology, 5th ed. Lippincott, Williams and Williams, Philadelphia 208: 78–108.
  11. Maciejewski B, Withers HR, Taylor JM, et al. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: tumor dose-response and repopulation. Int J Radiat Oncol Biol Phys. 1989; 16(3): 831–843.
  12. Harwood AR, Beale FA, Cummings BJ, et al. Supraglottic laryngeal carcinoma: an analysis of dose-time-volume factors in 410 patients. Int J Radiat Oncol Biol Phys. 1983; 9(3): 311–319.
  13. Van de, Ostoya F. van der Schueren E. The different clinical presentation, behavior and prognostic of carcinomas originating in the epilarynx and the lower supraglottis. Radiother Oncol. 1983; 1: 117–131.
  14. Wall TJ, Peters LJ, Brown BW, et al. Relationship between lymph nodal status and primary tumor control probability in tumors of the supraglottic larynx. Int J Radiat Oncol Biol Phys. 1985; 11(11): 1895–1902.
  15. Peters LJ, Withers HR, Thames HD, et al. Tumor radioresistance in clinical radiotherapy. Int J Radiat Oncol Biol Phys. 1982; 8(1): 101–108.
  16. Holm LE. Cellular DNA amounts of squamous cell carcinomas of the head and neck region in relation to prognosis. Laryngoscope. 1982; 92(9 Pt 1): 1064–1069.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest VM Media sp. z o.o. VM Group sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl