open access

Vol 70, No 6 (2020)
Review paper
Published online: 2020-10-07
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Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in axillary lymph nodes – a case report and review of 29 other cases from world literature

Przemysław Dymek1, Tomasz Błaszkowski1, Sandra Sienkiewicz1, Kajetan Kiełbowski1, Honorata Mruk1, Magdalena Lewandowska2, Aleksandra Kipczak1, Maciej Szyld1, Józef Kładny1
·
Nowotwory. Journal of Oncology 2020;70(6):244-249.
Affiliations
  1. Department of General and Oncological Surgery, Pomeranian Medical University, Szczecin, Poland
  2. Department of Pathology, Pomeranian Medical University, Szczecin, Poland

open access

Vol 70, No 6 (2020)
Review article
Published online: 2020-10-07

Abstract

Introduction. Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALC) is a new disease established by the WHO in 2016. BIA-ALCL is one of the most severe adverse effects of breast augmentation or breast reconstruction with the use of silicone implants.

Material and methods. In our report we present a case of a 46-year-old patient diagnosed with BIA-ALCL in the General and Oncological Surgery Clinic of the Pomeranian Medical University in Szczecin. This is one of the first described cases of this disease in Poland. Especially interesting is the fact that the lymphoma developed two years after the removal of the implants and the pathology occurred in the axillary lymph nodes. In order to compare the published case of BIA-ALCL we reviewed 29 cases from literature.

Results. We described the most clinically relevant factors. The age range of females analysed with diagnosed BIA-ALCL is between 27 to 87 years. The time from implant insertion to the appearance of the first symptoms varies. The use of textured implants seems to be one of the most important risk factors of novel lymphoma.

Conclusions. The patients with breast implants should be informed about the risk of BIA-ALCL and related symptoms. The number of articles about BIA-ALCL is minimal, therefore knowledge about the disease remains limited. There is a need to broaden knowledge about the pathological process, clinical manifestations, risk factors and medical tests crucial to achieve an accurate diagnosis.

Abstract

Introduction. Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALC) is a new disease established by the WHO in 2016. BIA-ALCL is one of the most severe adverse effects of breast augmentation or breast reconstruction with the use of silicone implants.

Material and methods. In our report we present a case of a 46-year-old patient diagnosed with BIA-ALCL in the General and Oncological Surgery Clinic of the Pomeranian Medical University in Szczecin. This is one of the first described cases of this disease in Poland. Especially interesting is the fact that the lymphoma developed two years after the removal of the implants and the pathology occurred in the axillary lymph nodes. In order to compare the published case of BIA-ALCL we reviewed 29 cases from literature.

Results. We described the most clinically relevant factors. The age range of females analysed with diagnosed BIA-ALCL is between 27 to 87 years. The time from implant insertion to the appearance of the first symptoms varies. The use of textured implants seems to be one of the most important risk factors of novel lymphoma.

Conclusions. The patients with breast implants should be informed about the risk of BIA-ALCL and related symptoms. The number of articles about BIA-ALCL is minimal, therefore knowledge about the disease remains limited. There is a need to broaden knowledge about the pathological process, clinical manifestations, risk factors and medical tests crucial to achieve an accurate diagnosis.

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Keywords

breast implant; lymphoma; lymphadenopathy; PET-CT; Poland

About this article
Title

Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in axillary lymph nodes – a case report and review of 29 other cases from world literature

Journal

Nowotwory. Journal of Oncology

Issue

Vol 70, No 6 (2020)

Article type

Review paper

Pages

244-249

Published online

2020-10-07

Page views

1272

Article views/downloads

879

DOI

10.5603/NJO.a2020.0044

Bibliographic record

Nowotwory. Journal of Oncology 2020;70(6):244-249.

Keywords

breast implant
lymphoma
lymphadenopathy
PET-CT
Poland

Authors

Przemysław Dymek
Tomasz Błaszkowski
Sandra Sienkiewicz
Kajetan Kiełbowski
Honorata Mruk
Magdalena Lewandowska
Aleksandra Kipczak
Maciej Szyld
Józef Kładny

References (34)
  1. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127(20): 2375–2390.
  2. Keech JA, Creech BJ. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg. 1997; 100(2): 554–555.
  3. Collett DJ, Rakhorst H, Lennox P, et al. Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants. Plast Reconstr Surg. 2019; 143(3S A Review of Breast Implant-Associated Anaplastic Large Cell Lymphoma): 30S–40S.
  4. Berlin E, Singh K, Mills C, et al. Breast Implant-Associated Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature. Case Rep Hematol. 2018; 2018: 2414278.
  5. Jones JL, Hanby AM, Wells C, et al. National Co-ordinating Committee of Breast Pathology. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): an overview of presentation and pathogenesis and guidelines for pathological diagnosis and management. Histopathology. 2019; 75(6): 787–796.
  6. Leberfinger AN, Behar BJ, Williams NC, et al. Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Systematic Review. JAMA Surg. 2017; 152(12): 1161–1168.
  7. Jacombs A, Tahir S, Hu H, et al. In vitro and in vivo investigation of the influence of implant surface on the formation of bacterial biofilm in mammary implants. Plast Reconstr Surg. 2014; 133(4): 471e–80e.
  8. Blombery P, Thompson ER, Jones K, et al. Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma. Haematologica. 2016; 101(9): e387–e390.
  9. Taylor KO, Webster HR, Prince HM. Anaplastic large cell lymphoma and breast implants: five Australian cases. Plast Reconstr Surg. 2012; 129(4): 610e–7e.
  10. de Boer M, van der Sluis WB, de Boer JP, et al. Breast Implant-Associated Anaplastic Large-Cell Lymphoma in a Transgender Woman. Aesthet Surg J. 2017; 37(8): NP83–NP87.
  11. Crèvecoeur J, Jossa V, Somja J, et al. Description of Two Cases of Anaplastic Large Cell Lymphoma Associated with a Breast Implant. Case Rep Radiol. 2019; 2019: 6137198.
  12. Carty MJ, Pribaz JJ, Antin JH, et al. A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast. Plast Reconstr Surg. 2011; 128(3): 112e–118e.
  13. Alderuccio JP, Desai A, Yepes MM, et al. Frontline brentuximab vedotin in breast implant-associated anaplastic large-cell lymphoma. Clin Case Rep. 2018; 6(4): 634–637.
  14. Hwang MJ, Brown H, Murrin R, et al. Breast implant-associated anaplastic large cell lymphoma: a case report and literature review. Aesthetic Plast Surg. 2015; 39(3): 391–395.
  15. Pastorello RG, D'Almeida Costa F, Osório CA, et al. Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report. Diagn Pathol. 2018; 13(1): 10.
  16. Richardson K, Alrifai T, Grant-Szymanski K, et al. Breast implant-associated anaplastic large-cell lymphoma and the role of brentuximab vedotin (SGN-35) therapy: A case report and review of the literature. Mol Clin Oncol. 2017; 6(4): 539–542.
  17. Olack B, Gupta R, Brooks GS. Anaplastic large cell lymphoma arising in a saline breast implant capsule after tissue expander breast reconstruction. Ann Plast Surg. 2007; 59(1): 56–57.
  18. Roden AC, Macon WR, Keeney GL, et al. Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder. Mod Pathol. 2008; 21(4): 455–463.
  19. Adlard J, Burton C, Turton P. Increasing Evidence for the Association of Breast Implant-Associated Anaplastic Large Cell Lymphoma and Li Fraumeni Syndrome. Case Rep Genet. 2019; 2019: 5647940.
  20. Ezekwudo DE, Ifabiyi T, Gbadamosi B, et al. Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report and Review of the Literature. Case Rep Oncol Med. 2017; 2017: 6478467.
  21. Fricke A, Wagner JA, Kricheldorff J, et al. Microbial detection in seroma fluid preceding the diagnosis of breast implant-associated anaplastic large cell lymphoma: a case report and review of the literature. Case Reports Plast Surg Hand Surg. 2019; 6(1): 116–120.
  22. Gardani M, Bellini E, Villani G, et al. Breast implant-associated anaplastic large cell lymphoma: A rare case report of lymphoma in the form of a pericapsular solid formation. Breast J. 2020; 26(2): 247–251.
  23. Patzelt M, Zarubova L, Klener P, et al. Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female. Aesthetic Plast Surg. 2018; 42(2): 451–455.
  24. Gaudet G, Friedberg JW, Weng A, et al. Breast lymphoma associated with breast implants: two case-reports and a review of the literature. Leuk Lymphoma. 2002; 43(1): 115–119.
  25. Sahoo S, Rosen PP, Feddersen RM, et al. Anaplastic large cell lymphoma arising in a silicone breast implant capsule: a case report and review of the literature. Arch Pathol Lab Med. 2003; 127: e115–e118.
  26. Alobeid B, Sevilla DW, El-Tamer MB, et al. Aggressive presentation of breast implant-associated ALK-1 negative anaplastic large cell lymphoma with bilateral axillary lymph node involvement. Leuk Lymphoma. 2009; 50(5): 831–833.
  27. Bishara MRY, Ross C, Sur M. Primary anaplastic large cell lymphoma of the breast arising in reconstruction mammoplasty capsule of saline filled breast implant after radical mastectomy for breast cancer: an unusual case presentation. Diagn Pathol. 2009; 4: 11.
  28. Wong AK, Lopategui J, Clancy S, et al. Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature. Am J Surg Pathol. 2008; 32(8): 1265–1268.
  29. Brody GS, Deapen D, Taylor CR, et al. Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg. 2015; 135(3): 695–705.
  30. Mehta-Shah N, Clemens MW, Horwitz SM. How I treat breast implant-associated anaplastic large cell lymphoma. Blood. 2018; 132(18): 1889–1898.
  31. DePaola NEK, Coggins H. Breast Implant-Associated Anaplastic Large Cell Lymphoma: What We Know. J Adv Pract Oncol. 2019; 10(1): 54–61.
  32. Kricheldorff J, Fallenberg EM, Solbach C, et al. Breast Implant-Associated Lymphoma. Dtsch Arztebl Int. 2018; 115(38): 628–635.
  33. Clemens MW, Jacobsen ED, Horwitz SM. 2019 NCCN Consensus Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). Aesthet Surg J. 2019; 39(Suppl_1): S3–SS13.
  34. Siminiak N, Czepczyński R. PET-CT for the staging of breast implant- -associated anaplastic large cell lymphoma. Nucl Med Rev Cent East Eur. 2019; 22(2): 90–91.

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