open access

Vol 71, No 6 (2021)
Research paper (original)
Published online: 2021-12-06
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The outcomes of limb-sparing surgery of patients with chondrosarcoma of the pelvis

Andrzej Pieńkowski1, Andrzej Komor23, Tomasz Goryń1, Bartłomiej Szostakowski1, Michał Wągrodzki4, Donata Makuła5, Patrycja Castaneda-Wysocka5, Wojciech Michalski6, Aneta Borkowska1, Piotr Rutkowski1
DOI: 10.5603/NJO.2021.0071
·
Nowotwory. Journal of Oncology 2021;71(6):336-342.
Affiliations
  1. Department of Bone, Soft Tissue Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw, Poland
  2. Institute of Mother and Child, Warsaw, Poland
  3. Carolina Medical Center, Warsaw, Poland
  4. Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw, Poland
  5. Department of Diagnostic Imaging, Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw, Poland
  6. Department of Oncological Mathematics, The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw, Poland

open access

Vol 71, No 6 (2021)
Original article
Published online: 2021-12-06

Abstract

Introduction.  Chondrosarcoma (ChSa) is the second most common primary malignant bone tumour, after osteosarco­ma. The aim of this study is to analyse the prognostic factors in patients operated on ChSa of the pelvic bone with limb sparing on the basis of a large retrospective group of patients. Aspects of the surgical technique are also presented, taking into account the location of the tumour within the pelvis. An attempt was also made to define the criteria for selecting patients for whom radical and limb-sparing surgery is possible.

Material and methods.  We analysed 53 consecutive patients with chondrosarcoma of the pelvic and sacral bones after surgery performed at the Department of Soft Tissue/Bone Sarcoma and Melanoma in Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland, between 1998 and 2020. Patients had surgery with sparing of the lower limb with the intention of cure.

Results.  There were 34 patients with G1 grade, G2 – 16, and G3 – 3. The R0 resection margin was achieved in 36 cases, the R1 margin in 11, and the R2 margin in 5 cases. The 5- and 10-year overall survival rates for the entire group were 84% and 65%, respectively. The 5-year and 10-year disease-free survival (DFS) probabilities were 65% and 43%, respectively.

Conclusions.  Multivariate analysis of the studied group of patients showed that the resection margin was a statistically significant factor determining prognosis (patients after R0 surgery margin have about 5 times lower death risk compared to patients after non-radical surgery with R1 or R2 margin).

Abstract

Introduction.  Chondrosarcoma (ChSa) is the second most common primary malignant bone tumour, after osteosarco­ma. The aim of this study is to analyse the prognostic factors in patients operated on ChSa of the pelvic bone with limb sparing on the basis of a large retrospective group of patients. Aspects of the surgical technique are also presented, taking into account the location of the tumour within the pelvis. An attempt was also made to define the criteria for selecting patients for whom radical and limb-sparing surgery is possible.

Material and methods.  We analysed 53 consecutive patients with chondrosarcoma of the pelvic and sacral bones after surgery performed at the Department of Soft Tissue/Bone Sarcoma and Melanoma in Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland, between 1998 and 2020. Patients had surgery with sparing of the lower limb with the intention of cure.

Results.  There were 34 patients with G1 grade, G2 – 16, and G3 – 3. The R0 resection margin was achieved in 36 cases, the R1 margin in 11, and the R2 margin in 5 cases. The 5- and 10-year overall survival rates for the entire group were 84% and 65%, respectively. The 5-year and 10-year disease-free survival (DFS) probabilities were 65% and 43%, respectively.

Conclusions.  Multivariate analysis of the studied group of patients showed that the resection margin was a statistically significant factor determining prognosis (patients after R0 surgery margin have about 5 times lower death risk compared to patients after non-radical surgery with R1 or R2 margin).

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Keywords

chondrosarcoma; pelvic bone; resection margin; histological malignancy grade

About this article
Title

The outcomes of limb-sparing surgery of patients with chondrosarcoma of the pelvis

Journal

Nowotwory. Journal of Oncology

Issue

Vol 71, No 6 (2021)

Article type

Research paper (original)

Pages

336-342

Published online

2021-12-06

DOI

10.5603/NJO.2021.0071

Bibliographic record

Nowotwory. Journal of Oncology 2021;71(6):336-342.

Keywords

chondrosarcoma
pelvic bone
resection margin
histological malignancy grade

Authors

Andrzej Pieńkowski
Andrzej Komor
Tomasz Goryń
Bartłomiej Szostakowski
Michał Wągrodzki
Donata Makuła
Patrycja Castaneda-Wysocka
Wojciech Michalski
Aneta Borkowska
Piotr Rutkowski

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