open access
Significance of genetic and radiological examinations in diagnosis and therapy of brain glioma in adult patients
Affiliations- Department of Genetics, Wroclaw Medical University, Wroclaw, Poland
- Lower Silesian Oncology Centre in Wroclaw, Poland
- Department of General and Interventional Radiology and Neuroradiology, Chair of Radiology, Wroclaw Medical University, Wroclaw, Poland
open access
Abstract
Molecular and imaging studies are applied along with histopathology in diagnosis and differential diagnosis of brain gliomas and they enable personalised clinical management. With knowledge of the patient’s clinical condition, a decision whether to observe the patient or proceed to immediate surgical treatment is made based on imaging results. On the other hand, knowledge of molecular predictive markers allows optimisation of chemotherapeutic decisions, e.g., introduction of personalised therapy (application of such drugs as temozolomide, bevacizumab, vemurafenib, dabrafenib and trametinib).
Abstract
Molecular and imaging studies are applied along with histopathology in diagnosis and differential diagnosis of brain gliomas and they enable personalised clinical management. With knowledge of the patient’s clinical condition, a decision whether to observe the patient or proceed to immediate surgical treatment is made based on imaging results. On the other hand, knowledge of molecular predictive markers allows optimisation of chemotherapeutic decisions, e.g., introduction of personalised therapy (application of such drugs as temozolomide, bevacizumab, vemurafenib, dabrafenib and trametinib).
Keywords
brain gliomas; personalised medicine; molecular diagnostics; imaging diagnostics; MRI; perfusion MRI; MR spectroscopy; diffusion tensor MRI; fMRI; temozolomide; bevacizumab
About this articleTitle
Significance of genetic and radiological examinations in diagnosis and therapy of brain glioma in adult patients
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
328-334
Published online
2021-10-13
Page views
6263
Article views/downloads
335
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2021;71(5):328-334.
Keywords
brain gliomas
personalised medicine
molecular diagnostics
imaging diagnostics
MRI
perfusion MRI
MR spectroscopy
diffusion tensor MRI
fMRI
temozolomide
bevacizumab
Authors
Gabriela Janus-Szymańska
Łukasz Waszczuk
Jagoda Jacków-Nowicka
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