open access

Vol 71, No 5 (2021)
Review paper
Published online: 2021-10-13
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Significance of genetic and radiological examinations in diagnosis and therapy of brain glioma in adult patients

Gabriela Janus-Szymańska12, Łukasz Waszczuk3, Jagoda Jacków-Nowicka3
DOI: 10.5603/NJO.2021.0062
·
Nowotwory. Journal of Oncology 2021;71(5):328-334.
Affiliations
  1. Department of Genetics, Wroclaw Medical University, Wroclaw, Poland
  2. Lower Silesian Oncology Centre in Wroclaw, Poland
  3. Department of General and Interventional Radiology and Neuroradiology, Chair of Radiology, Wroclaw Medical University, Wroclaw, Poland

open access

Vol 71, No 5 (2021)
Genetics and oncology
Published online: 2021-10-13

Abstract

Molecular and imaging studies are applied along with histopathology in diagnosis and differential diagnosis of brain gliomas and they enable personalised clinical management. With knowledge of the patient’s clinical condition, a decision whether to observe the patient or proceed to immediate surgical treatment is made based on imaging results. On the other hand, knowledge of molecular predictive markers allows optimisation of chemotherapeutic decisions, e.g., introduction of personalised therapy (application of such drugs as temozolomide, bevacizumab, vemurafenib, dabrafenib and trametinib).

Abstract

Molecular and imaging studies are applied along with histopathology in diagnosis and differential diagnosis of brain gliomas and they enable personalised clinical management. With knowledge of the patient’s clinical condition, a decision whether to observe the patient or proceed to immediate surgical treatment is made based on imaging results. On the other hand, knowledge of molecular predictive markers allows optimisation of chemotherapeutic decisions, e.g., introduction of personalised therapy (application of such drugs as temozolomide, bevacizumab, vemurafenib, dabrafenib and trametinib).

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Keywords

brain gliomas; personalised medicine; molecular diagnostics; imaging diagnostics; MRI; perfusion MRI; MR spectroscopy; diffusion tensor MRI; fMRI; temozolomide; bevacizumab

About this article
Title

Significance of genetic and radiological examinations in diagnosis and therapy of brain glioma in adult patients

Journal

Nowotwory. Journal of Oncology

Issue

Vol 71, No 5 (2021)

Article type

Review paper

Pages

328-334

Published online

2021-10-13

DOI

10.5603/NJO.2021.0062

Bibliographic record

Nowotwory. Journal of Oncology 2021;71(5):328-334.

Keywords

brain gliomas
personalised medicine
molecular diagnostics
imaging diagnostics
MRI
perfusion MRI
MR spectroscopy
diffusion tensor MRI
fMRI
temozolomide
bevacizumab

Authors

Gabriela Janus-Szymańska
Łukasz Waszczuk
Jagoda Jacków-Nowicka

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