open access

Vol 70, No 6 (2020)
Other materials agreed with the Editors
Published online: 2020-12-04
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Advances in the management of gastrointestinal stromal tumors (GISTs)

Monika Dudzisz-Śledź, Piotr Rutkowski
DOI: 10.5603/NJO.2020.0055
·
Nowotwory. Journal of Oncology 2020;70(6):280-287.

open access

Vol 70, No 6 (2020)
Conference addendum
Published online: 2020-12-04

Abstract

Gastrointestinal stromal tumors are rare neoplasms developing from cells of Cajal in the gastrointestinal tract. The mainstay of such tumors treatment is surgery, whenever possible. The therapeutic management of inoperable and metastatic disease is based on tyrosine kinase inhibitors and imatinib is the main drug recommended for first line treatment. The introduction of imatinib and other inhibitors improved survival outcomes for this disease, but due to primary and secondary resistance there is still the urgent need for new medications. This paper presents the progress in the systemic therapy of GISTs based on the latest scientific data. The newly developed agents (ripretinib, avapritinib) meet the need to treat patients after the failure of previously available therapies and those with PDGFRA mutation D842V associated with resistance to imatinib.

Abstract

Gastrointestinal stromal tumors are rare neoplasms developing from cells of Cajal in the gastrointestinal tract. The mainstay of such tumors treatment is surgery, whenever possible. The therapeutic management of inoperable and metastatic disease is based on tyrosine kinase inhibitors and imatinib is the main drug recommended for first line treatment. The introduction of imatinib and other inhibitors improved survival outcomes for this disease, but due to primary and secondary resistance there is still the urgent need for new medications. This paper presents the progress in the systemic therapy of GISTs based on the latest scientific data. The newly developed agents (ripretinib, avapritinib) meet the need to treat patients after the failure of previously available therapies and those with PDGFRA mutation D842V associated with resistance to imatinib.

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Keywords

gastrointestinal stromal tumor; GIST; tyrosine kinase inhibitor; imatinib; regorafenib; sunitinib; sorafenib; avapritinib; repritinib; BLU-285; DCC-2618

About this article
Title

Advances in the management of gastrointestinal stromal tumors (GISTs)

Journal

Nowotwory. Journal of Oncology

Issue

Vol 70, No 6 (2020)

Article type

Other materials agreed with the Editors

Pages

280-287

Published online

2020-12-04

DOI

10.5603/NJO.2020.0055

Bibliographic record

Nowotwory. Journal of Oncology 2020;70(6):280-287.

Keywords

gastrointestinal stromal tumor
GIST
tyrosine kinase inhibitor
imatinib
regorafenib
sunitinib
sorafenib
avapritinib
repritinib
BLU-285
DCC-2618

Authors

Monika Dudzisz-Śledź
Piotr Rutkowski

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