Vol 70, No 1 (2020)
Case report
Published online: 2020-03-03
Malignant granular cell tumor of the lumbar region – a case report and review of the criteria for diagnosis
Nowotwory. Journal of Oncology 2020;70(1):33-36.
Abstract
We report an unusual case of a malignant granular cell tumor of the left lumbar region in 63-year old woman – diagnosed, consulted and treated with surgical resection (R1) and radiotherapy, followed up for 2 years with lung metastases after 22 months. Furthermore, we discuss histopathological differential diagnosis and current criteria for malignancy, as well as available options for systemic treatment in view of cytogenetic and molecular genetic characteristics of the tumor.
Keywords: granular cell tumormalignant granular cell tumordifferential diagnosisimmunophenotype
References
- Abrikossoff A. Über Myome. Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin. 1926; 260(1): 215–233.
- Ravich A, Stout AP, Ravich RA. Malignant Granular Cell Myoblastoma Involving the Urinary Bladder. Ann Surg. 1945; 121(3): 361–372.
- Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998; 22(7): 779–794.
- Curtis BV, Calcaterra TC, Coulson WF. Multiple granular cell tumor: a case report and review of the literature. Head Neck. 1997; 19(7): 634–637.
- Nasser H, Ahmed Y, Szpunar SM, et al. Malignant granular cell tumor: a look into the diagnostic criteria. Pathol Res Pract. 2011; 207(3): 164–168.
- Cui Y, Tong SS, Zhang YH, et al. Granular cell tumor: A report of three cases and review of literature. Cancer Biomark. 2018; 23(2): 173–178.
- Jaloux C, Degardin N, Cegarra-Escolano M, et al. A thoracic parasternal granular cell tumor in a child: About one case and review of the literature, discussion about treatment guidelines, is complete resection compulsory? Ann Chir Plast Esthet. 2017; 62(3): 251–254.
- Tsukamoto S, Takeda M, Honoki K, et al. Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases. Skeletal Radiol. 2019; 48(2): 307–316.
- Fletcher CDM. Organization W.H. WHO Classification of Tumours of Soft Tissue and Bone. IARC Press 2013.
- Chamberlain BK, McClain CM, Gonzalez RS, et al. Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study. Hum Pathol. 2014; 45(5): 1039–1044.
- Marchand Crety C, Garbar C, Madelis G, et al. Adjuvant radiation therapy for malignant Abrikossoff's tumor: a case report about a femoral triangle localisation. Radiat Oncol. 2018; 13(1): 115.
- Xu S, Zhao Q, Wei S, et al. Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor. J Thorac Oncol. 2015; 10(10): e106–e109.
- Wei L, Liu S, Conroy J, et al. Whole-genome sequencing of a malignant granular cell tumor with metabolic response to pazopanib. Cold Spring Harb Mol Case Stud. 2015; 1(1): a000380.
- Conley A, Koplin S, Caracciollo J, et al. Dramatic Response to Pazopanib in a Patient With Metastatic Malignant Granular Cell Tumor. J Clin Oncol. 2014; 32(32): e107–e110.
- Morita S, Hiramatsu M, Sugishita M, et al. Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report. Oncol Lett. 2015; 10(2): 972–974.
- Graaf Wv, Blay JY, Chawla S, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012; 379(9829): 1879–1886.