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Should perioperative chemotherapy in triple negative breast cancer routinely comprise platinum salts? A vote for no
Affiliations- Department and Chair of Electroradiology, Chemotherapy Department, The Maria Skłodowska–Curie Greater Poland Cancer Centre, Poznan University of Medical Sciences, Poznan, Poland
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Abstract
Breast cancer is the most common female neoplasm in Poland and worldwide, its mortality rate ranking second only to lung cancer. There are several biological subtypes, differing, among other parameters, as to prognosis and perioperative treatment recommendations. Triple negative breast cancer is one of the worst prognoses and systemic preoperative treatment is recommended as early as of II TNM stage. Pathological complete response (pCR) may result in an improved prognosis. Most patients respond well to standard chemotherapy and there is no need to include platinum derivatives in perioperative therapies. One should remember that platinum salts use not only increases the percentage of pCRs, but also results in an increased therapeutic toxicity; it does not, however, have an impact on disease free survival (DFS) an overall survival (OS).
Abstract
Breast cancer is the most common female neoplasm in Poland and worldwide, its mortality rate ranking second only to lung cancer. There are several biological subtypes, differing, among other parameters, as to prognosis and perioperative treatment recommendations. Triple negative breast cancer is one of the worst prognoses and systemic preoperative treatment is recommended as early as of II TNM stage. Pathological complete response (pCR) may result in an improved prognosis. Most patients respond well to standard chemotherapy and there is no need to include platinum derivatives in perioperative therapies. One should remember that platinum salts use not only increases the percentage of pCRs, but also results in an increased therapeutic toxicity; it does not, however, have an impact on disease free survival (DFS) an overall survival (OS).
Keywords
breast cancer; triple negative breast cancer; perioperative therapy; platinum salts
About this articleTitle
Should perioperative chemotherapy in triple negative breast cancer routinely comprise platinum salts? A vote for no
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Other materials agreed with the Editors
Pages
182-183
Published online
2019-12-31
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888
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522
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2019;69(5-6):182-183.
Keywords
breast cancer
triple negative breast cancer
perioperative therapy
platinum salts
Authors
Joanna Kufel-Grabowska