open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31
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Merkel cell carcinoma (MCC) – neuroendocrine skin cancer

Monika Dudzisz-Śledź, Marcin Zdzienicki, Piotr Rutkowski
DOI: 10.5603/NJO.2019.0022
·
Nowotwory. Journal of Oncology 2019;69(3-4):111-116.

open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31

Abstract

Merkel cell carcinoma (MCC) is a rarely occurring skin cancer of high malignancy. It develops, most probably, from the neuroendocrine cells (Merkel’s cells). The most frequent location of this cancer is the skin of the head and neck (44–48% of cases), and then in the skin of the upper limbs (about 19% of cases) and then the lower limbs (16–20% of cases). The aetiology of this cancer is unknown, yet some role in its pathogenesis is played by ultraviolet light and immunosuppression. The basis of therapy in cases with locoregional spread is surgical intervention, whilst in more advanced cases, an effective systemic treatment is possible with the use of molecularly targeted therapies. This paper presents the current treatment possibilities in patients with Merkel cell carcinoma.

Abstract

Merkel cell carcinoma (MCC) is a rarely occurring skin cancer of high malignancy. It develops, most probably, from the neuroendocrine cells (Merkel’s cells). The most frequent location of this cancer is the skin of the head and neck (44–48% of cases), and then in the skin of the upper limbs (about 19% of cases) and then the lower limbs (16–20% of cases). The aetiology of this cancer is unknown, yet some role in its pathogenesis is played by ultraviolet light and immunosuppression. The basis of therapy in cases with locoregional spread is surgical intervention, whilst in more advanced cases, an effective systemic treatment is possible with the use of molecularly targeted therapies. This paper presents the current treatment possibilities in patients with Merkel cell carcinoma.

Get Citation

Keywords

Merkel cell carcinoma; diagnostics; surgical treatment; systemic treatment

About this article
Title

Merkel cell carcinoma (MCC) – neuroendocrine skin cancer

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 3-4 (2019)

Pages

111-116

Published online

2019-10-31

DOI

10.5603/NJO.2019.0022

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(3-4):111-116.

Keywords

Merkel cell carcinoma
diagnostics
surgical treatment
systemic treatment

Authors

Monika Dudzisz-Śledź
Marcin Zdzienicki
Piotr Rutkowski

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