open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31
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New developments in the perioperative treatment of melanomas with locoregional advancement

Piotr Rutkowski, Wojciech M. Wysocki, Tomasz Świtaj, Arkadiusz Jeziorski
DOI: 10.5603/NJO.2019.0019
·
Nowotwory. Journal of Oncology 2019;69(3-4):97-102.

open access

Vol 69, No 3-4 (2019)
Review articles
Published online: 2019-10-31

Abstract

Surgical intervention is the treatment of choice for patients with melanomas. However, the prognoses of the patients with melanomas at the IIC–IV stage, even after a complete resection of the lesions, is very diverse and, to a great degree, connected with a high risk of disease recurrence. The positive results of the studies in this area have resulted in systemic adjuvant therapy becoming the standard for patients in this group. New methods of systemic treatment – both the mo­lecularly targeted treatment with BRAF and MEK inhibitors (dabrafenib with trametinib) and anti-PD-1 immunotherapy (nivolumab or pembrolizumab) – are already registered in the United States and the European Union. Also the results of the studies concerning the use of preoperative systemic treatment in patients with loco-regionally advanced melanomas seem to be very promising.

Abstract

Surgical intervention is the treatment of choice for patients with melanomas. However, the prognoses of the patients with melanomas at the IIC–IV stage, even after a complete resection of the lesions, is very diverse and, to a great degree, connected with a high risk of disease recurrence. The positive results of the studies in this area have resulted in systemic adjuvant therapy becoming the standard for patients in this group. New methods of systemic treatment – both the mo­lecularly targeted treatment with BRAF and MEK inhibitors (dabrafenib with trametinib) and anti-PD-1 immunotherapy (nivolumab or pembrolizumab) – are already registered in the United States and the European Union. Also the results of the studies concerning the use of preoperative systemic treatment in patients with loco-regionally advanced melanomas seem to be very promising.

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Keywords

melanoma; adjuvant treatment; preoperative treatment; BRAF inhibitors; MEK inhibitors; immunotherapy; anti-PD-1

About this article
Title

New developments in the perioperative treatment of melanomas with locoregional advancement

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 3-4 (2019)

Pages

97-102

Published online

2019-10-31

DOI

10.5603/NJO.2019.0019

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(3-4):97-102.

Keywords

melanoma
adjuvant treatment
preoperative treatment
BRAF inhibitors
MEK inhibitors
immunotherapy
anti-PD-1

Authors

Piotr Rutkowski
Wojciech M. Wysocki
Tomasz Świtaj
Arkadiusz Jeziorski

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