open access

Vol 69, No 3-4 (2019)
Original articles
Published online: 2019-10-31
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Apocrine breast carcinoma as an extremely rare breast cancer subtype – histopathological characteristics

Marta Maksimiuk, Michał P. Budzik, Aleksandra Sobiborowicz, Anna Maria Badowska-Kozakiewicz
DOI: 10.5603/NJO.2019.0017
·
Nowotwory. Journal of Oncology 2019;69(3-4):83-85.

open access

Vol 69, No 3-4 (2019)
Original articles
Published online: 2019-10-31

Abstract

Apocrine carcinoma (AC) is a distinctive and rare type of malignancy, counted for 0.3–4% of all breast cancer cases. It does not have a particular clinical or radiological features, although it is characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile. In the present study, among 1122 patients with breast cancer only 5 of them were diagnosed with apocrine carcinoma (0.4%). All patients were above 50 years old (51–63, mean: 57). Tumor size varied from 1.4 cm to 3.8 cm with a mean size of 2.4 cm, while mean size of all 1122 studied cases counted for 1.9 cm. Two tumors were classified as high-grade (G3), 2 as G2, and 1 as G1. Four tumors out of 5 did not affect lymph nodes (pN0 stage), whereas 1 was classified as pN2 with 9/19 regional lymph nodes affected. This observation was consistent with the whole studied group, in which pN0 stage made up the largest percentage. Presented results suggest that AC is less frequent in premenopausal patients. AC tends to present as invasive malignancy without nodal involvement and is usually characterized by relatively less aggressive biological behavior compared to other histological types of breast cancer. Due to the fact that AC is definitely a rare type of breast cancer, modern medicine has still limited treatment options to offer. Further research needs to be conducted in order to develop target therapies for this carcinoma.

Abstract

Apocrine carcinoma (AC) is a distinctive and rare type of malignancy, counted for 0.3–4% of all breast cancer cases. It does not have a particular clinical or radiological features, although it is characterized by the apocrine morphology, estrogen receptor-negative and androgen receptor-positive profile. In the present study, among 1122 patients with breast cancer only 5 of them were diagnosed with apocrine carcinoma (0.4%). All patients were above 50 years old (51–63, mean: 57). Tumor size varied from 1.4 cm to 3.8 cm with a mean size of 2.4 cm, while mean size of all 1122 studied cases counted for 1.9 cm. Two tumors were classified as high-grade (G3), 2 as G2, and 1 as G1. Four tumors out of 5 did not affect lymph nodes (pN0 stage), whereas 1 was classified as pN2 with 9/19 regional lymph nodes affected. This observation was consistent with the whole studied group, in which pN0 stage made up the largest percentage. Presented results suggest that AC is less frequent in premenopausal patients. AC tends to present as invasive malignancy without nodal involvement and is usually characterized by relatively less aggressive biological behavior compared to other histological types of breast cancer. Due to the fact that AC is definitely a rare type of breast cancer, modern medicine has still limited treatment options to offer. Further research needs to be conducted in order to develop target therapies for this carcinoma.

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Keywords

apocrine breast carcinoma; breast cancer; estrogen receptor; progesterone receptor; HER2

About this article
Title

Apocrine breast carcinoma as an extremely rare breast cancer subtype – histopathological characteristics

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 3-4 (2019)

Pages

83-85

Published online

2019-10-31

DOI

10.5603/NJO.2019.0017

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(3-4):83-85.

Keywords

apocrine breast carcinoma
breast cancer
estrogen receptor
progesterone receptor
HER2

Authors

Marta Maksimiuk
Michał P. Budzik
Aleksandra Sobiborowicz
Anna Maria Badowska-Kozakiewicz

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