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Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review
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Abstract
Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).
Abstract
Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).
Keywords
leiomyosarcoma, secondary neoplasms, radiotherapy, nibrin
About this articleTitle
Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Case report
Pages
65-66
Published online
2019-08-02
Page views
520
Article views/downloads
543
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2019;69(2):65-66.
Keywords
leiomyosarcoma
secondary neoplasms
radiotherapy
nibrin
Authors
Anna Romanowska
Joanna Gajda
Jacek Jassem
Rafał Pęksa
Renata Zaucha