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SOX10 as an immunohistochemical marker in cancer diagnostics
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Abstract
SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.
Abstract
SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.
Keywords
SOX10 protein, immunohistochemistry, melanocytic marker, malignant peripheral nerve sheath tumor, anti-SOX10 antibodies
About this articleTitle
SOX10 as an immunohistochemical marker in cancer diagnostics
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
58-64
Published online
2019-08-02
Page views
478
Article views/downloads
5373
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2019;69(2):58-64.
Keywords
SOX10 protein
immunohistochemistry
melanocytic marker
malignant peripheral nerve sheath tumor
anti-SOX10 antibodies
Authors
Beata Pytlak
Monika Prochorec-Sobieszek
Anna Szumera-Ciećkiewicz