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Surgical treatment of metastatic gallbladder cancer. Systematic review with own experience
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Abstract
Introduction. Patients with metastatic gallbladder cancer (GBC) are generally considered incurable and compelled to palliative chemotherapy. Nevertheless, there are numerous reports of successful surgical management of metastatic GBC. The impact of such treatment is yet unclear. Material and methods. We conducted a systematic literature review within Medline and Scopus databases using the following pattern: “gallbladder” and “cancer” and “dissemination”. Also, our own experience with two resected metastatic GBC patients was added to the results. Discussion. The literature search yielded 8 publications with a total of hundred and twelve patients fulfilling the inclusion criteria. Two additional patients were included in the analysis: one with resected GBC liver metastasis and the second with resected GBC diaphragmatic metastasis. A total of hundred and fourteen patients who underwent resection of a solid organ GBC metastasis were analyzed. The study confirmed a rare long-term survival after resection of an isolated GBC metastasis. Conclusions. There is no clear indication for surgical management of gallbladder cancer metastasis. In selected cases, an aggressive surgical approach may be justified.
Abstract
Introduction. Patients with metastatic gallbladder cancer (GBC) are generally considered incurable and compelled to palliative chemotherapy. Nevertheless, there are numerous reports of successful surgical management of metastatic GBC. The impact of such treatment is yet unclear. Material and methods. We conducted a systematic literature review within Medline and Scopus databases using the following pattern: “gallbladder” and “cancer” and “dissemination”. Also, our own experience with two resected metastatic GBC patients was added to the results. Discussion. The literature search yielded 8 publications with a total of hundred and twelve patients fulfilling the inclusion criteria. Two additional patients were included in the analysis: one with resected GBC liver metastasis and the second with resected GBC diaphragmatic metastasis. A total of hundred and fourteen patients who underwent resection of a solid organ GBC metastasis were analyzed. The study confirmed a rare long-term survival after resection of an isolated GBC metastasis. Conclusions. There is no clear indication for surgical management of gallbladder cancer metastasis. In selected cases, an aggressive surgical approach may be justified.
Keywords
gallbladder cancer, metastatic disease, surgery
About this articleTitle
Surgical treatment of metastatic gallbladder cancer. Systematic review with own experience
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
43-46
Published online
2019-08-02
Page views
471
Article views/downloads
680
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2019;69(2):43-46.
Keywords
gallbladder cancer
metastatic disease
surgery
Authors
Oleksandr Legkiy
Dagmara Kozłowska
Jacek Mazur
Andrzej L. Komorowski