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The importance of Helicobacter pylori in the development of gastric MALT lymphoma — induction of proliferation and immune suppression
Affiliations- Department of Microbiology, Wroclaw Medical University, Poland
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Abstract
Marginal zone B-cell lymphomas are indolent, slow-growing lymphomas derived from mature B cells. They represent about 8% of all lymphomas and about 50% of all primary gastric lymphomas. Based on numerous epidemiological and microbiological studies, Helicobacter pylori is believed to be responsible for the progression of gastric MALT lymphomas (GML). Lymphoid tissue is physiologically absent from the stomach. However, GML can arise from chronic H. pylori infection and immune cell infiltration. This review article describes the mechanisms favouring the development of H. pylori-induced GML, and suggests potential targets for a more effective remission of lymphomas localized within the stomach.
Abstract
Marginal zone B-cell lymphomas are indolent, slow-growing lymphomas derived from mature B cells. They represent about 8% of all lymphomas and about 50% of all primary gastric lymphomas. Based on numerous epidemiological and microbiological studies, Helicobacter pylori is believed to be responsible for the progression of gastric MALT lymphomas (GML). Lymphoid tissue is physiologically absent from the stomach. However, GML can arise from chronic H. pylori infection and immune cell infiltration. This review article describes the mechanisms favouring the development of H. pylori-induced GML, and suggests potential targets for a more effective remission of lymphomas localized within the stomach.
Keywords
Helicobacter pylori, immunosuppression, MALT lymphoma, proliferation, stomach
About this articleTitle
The importance of Helicobacter pylori in the development of gastric MALT lymphoma — induction of proliferation and immune suppression
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
261-266
Published online
2017-12-29
Page views
511
Article views/downloads
690
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2017;67(4):261-266.
Keywords
Helicobacter pylori
immunosuppression
MALT lymphoma
proliferation
stomach
Authors
Paweł Krzyżek
Barbara Kwiatkowska