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Vol 66, No 4 (2016)
Review paper
Published online: 2016-12-23
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Hippocampal sparing in brain radiotherapy

Monika Konopka-Filippow, Ewa Sierko, Marek Z. Wojtukiewicz
DOI: 10.5603/NJO.2016.0057
·
Nowotwory. Journal of Oncology 2016;66(4):299-306.

open access

Vol 66, No 4 (2016)
Review article
Published online: 2016-12-23

Abstract

Radiotherapy is one of the principal methods for treating brain cancer. Over recent years, a decline in patient quality of life has increasingly been observed in those undergoing brain irradiation, where hippocampal-dependent cognitive function has become impaired. The hippocampus is a paired structure of the limbic system situated in the medial temporal lobes of the telencephalon. Preliminary findings suggest that irradiation damaged neural stem cells in the hippocampus undergo apoptosis, resulting in deteriorating cognitive function. Despite the technical aspects for affording hippocampal avoidance during irradiation, much controversy still surrounds the techniques that shield the hippocampus without reducing the benefits of the intended radiotherapy for a given clinical condition. Furthermore, a tolerated radiation dose sufficient for preserving neural stem cell function has not been yet established. Delivering a method for an unequivocal assessment of cognitive function, post-irradiation, is also fraught with difficulty. Hitherto, only subjective psychological testing have been applied such as MMSE, HVLT or AVLT methods. Objective methods for optimally determining radiation-induced injury to the hippocampal region are still being investigated.  

Abstract

Radiotherapy is one of the principal methods for treating brain cancer. Over recent years, a decline in patient quality of life has increasingly been observed in those undergoing brain irradiation, where hippocampal-dependent cognitive function has become impaired. The hippocampus is a paired structure of the limbic system situated in the medial temporal lobes of the telencephalon. Preliminary findings suggest that irradiation damaged neural stem cells in the hippocampus undergo apoptosis, resulting in deteriorating cognitive function. Despite the technical aspects for affording hippocampal avoidance during irradiation, much controversy still surrounds the techniques that shield the hippocampus without reducing the benefits of the intended radiotherapy for a given clinical condition. Furthermore, a tolerated radiation dose sufficient for preserving neural stem cell function has not been yet established. Delivering a method for an unequivocal assessment of cognitive function, post-irradiation, is also fraught with difficulty. Hitherto, only subjective psychological testing have been applied such as MMSE, HVLT or AVLT methods. Objective methods for optimally determining radiation-induced injury to the hippocampal region are still being investigated.  

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Keywords

hippocampal sparing, brain radiotherapy, cognitive function

About this article
Title

Hippocampal sparing in brain radiotherapy

Journal

Nowotwory. Journal of Oncology

Issue

Vol 66, No 4 (2016)

Article type

Review paper

Pages

299-306

Published online

2016-12-23

Page views

1096

Article views/downloads

2168

DOI

10.5603/NJO.2016.0057

Bibliographic record

Nowotwory. Journal of Oncology 2016;66(4):299-306.

Keywords

hippocampal sparing
brain radiotherapy
cognitive function

Authors

Monika Konopka-Filippow
Ewa Sierko
Marek Z. Wojtukiewicz

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