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Classical variant of infiltrating lobular breast cancer seen in the Oncology Centre in Krakow: clinical characteristics, results of therapy and prognostic factors in patients treated 1980–2005
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Abstract
Introduction. Infiltrating lobular breast cancer (ILC) accounts for approximately 5–10% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for classical variant of ILC (C-ILC).
Material and methods. The analysis was performed in group of 220 patients with C-ILC treated between 1980 and 2005. Stage I or II cancer was found in 67.7% patients, and in 172 patients (78.2%) the tumour diameter was lower than 5 cm (78.2%), 121 patients (55%) did not develop lymph node metastases. Immunohistochemical analysis showed estrogen receptor positivity (80.9%), progesterone receptor positivity (72.7%) and expression of HER2/neu (3.7%). The multifocal changes were present in 14 cases (6.4%). All patients received surgical treatment: mastectomy (189 — 85.9%) or breast-conserving therapy (31 — 14.1%). The adiuvant treatment consisted of radiotherapy (141 patients — 64.1%), chemotherapy (35 patients — 15.9%) and hormonotherapy (120 patients — 54.5%).
Results. The 10-year disease-free survival rate was 65%. Multivariate analysis showed that an independent statistically significant prognostic factor was microscopic status of axillary lymph nodes. During follow-up the development of breast cancer in the second breast was observed in 19 patients ( 8.6%) and 55 patients (25%) developed distant metastases.
Conclusions. The C-ILC has some specific clinico-pathological characteristics and it is possible to perform breast- -conserving treatment in these cases. The negative prognostic factor is the presence of lymph node metastases.
Abstract
Introduction. Infiltrating lobular breast cancer (ILC) accounts for approximately 5–10% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for classical variant of ILC (C-ILC).
Material and methods. The analysis was performed in group of 220 patients with C-ILC treated between 1980 and 2005. Stage I or II cancer was found in 67.7% patients, and in 172 patients (78.2%) the tumour diameter was lower than 5 cm (78.2%), 121 patients (55%) did not develop lymph node metastases. Immunohistochemical analysis showed estrogen receptor positivity (80.9%), progesterone receptor positivity (72.7%) and expression of HER2/neu (3.7%). The multifocal changes were present in 14 cases (6.4%). All patients received surgical treatment: mastectomy (189 — 85.9%) or breast-conserving therapy (31 — 14.1%). The adiuvant treatment consisted of radiotherapy (141 patients — 64.1%), chemotherapy (35 patients — 15.9%) and hormonotherapy (120 patients — 54.5%).
Results. The 10-year disease-free survival rate was 65%. Multivariate analysis showed that an independent statistically significant prognostic factor was microscopic status of axillary lymph nodes. During follow-up the development of breast cancer in the second breast was observed in 19 patients ( 8.6%) and 55 patients (25%) developed distant metastases.
Conclusions. The C-ILC has some specific clinico-pathological characteristics and it is possible to perform breast- -conserving treatment in these cases. The negative prognostic factor is the presence of lymph node metastases.
About this articleTitle
Classical variant of infiltrating lobular breast cancer seen in the Oncology Centre in Krakow: clinical characteristics, results of therapy and prognostic factors in patients treated 1980–2005
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
26-34
Published online
2016-04-07
Page views
1063
Article views/downloads
16286
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2016;66(1):26-34.
Authors
Piotr Skotnicki
Łukasz Wohadlo
Beata Sas-Korczyńska
Marian Reinfuss
Jerzy W. Mituś
Tomasz Walasek