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Overuse of granulocyte colony stimulating factors in systemic cancer therapy
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Abstract
The use of granulopoietic agents has become widespread in cancer patients receiving chemotherapy, and a number of reliable population-based studies suggest major deviations from the international evidence-based guidelines. In effect, the growth factors are overused or not used when clinically indicated. In addition, recent randomised studies in patients with aggressive lymphoma provide evidence against the benefit of once commonly believed tactics of dose-dense chemotherapy made possible by the use of G-CSF. We review of contributions implicating an overuse or underuse of G-CSF in oncology practice.
Abstract
The use of granulopoietic agents has become widespread in cancer patients receiving chemotherapy, and a number of reliable population-based studies suggest major deviations from the international evidence-based guidelines. In effect, the growth factors are overused or not used when clinically indicated. In addition, recent randomised studies in patients with aggressive lymphoma provide evidence against the benefit of once commonly believed tactics of dose-dense chemotherapy made possible by the use of G-CSF. We review of contributions implicating an overuse or underuse of G-CSF in oncology practice.
About this articleTitle
Overuse of granulocyte colony stimulating factors in systemic cancer therapy
Journal
Nowotwory. Journal of Oncology
Issue
Pages
529-534
Published online
2016-02-05
Page views
694
Article views/downloads
1860
DOI
10.5603/NJO.2015.0108
Bibliographic record
Nowotwory. Journal of Oncology 2015;65(6):529-534.
Authors
Jan Walewski