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Vol 64, No 4 (2014)
Irradiation techniques
Published online: 2014-09-01
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Method of total marrow irradiation (TMI)

Grzegorz Głowacki, Leszek Miszczyk, Krzysztof Ślosarek, Bożena Jochymek, Grzegorz Woźniak, Łukasz Matulewicz, Michał Radwan, Paulina Leszczyńska, Łukasz Dolla, Jacek Najda, Tomasz Krużel, Tomasz Czerw, Maria Saduś-Wojciechowska, Sebastian Giebel
DOI: 10.5603/NJO.2014.0052
·
Nowotwory. Journal of Oncology 2014;64(4):314-320.

open access

Vol 64, No 4 (2014)
Irradiation techniques
Published online: 2014-09-01

Abstract

Allogenic and autologous hematopoietic stem cell transplantation (HSCT) is widely used for the treatment of manymyeloid and lymphoid malignancies. Conditioning precedes bone marrow transplantation. Chemotherapy alone or with radiotherapy (TBI — total bone marrow irradiation) are used to conditioning. The proven efficacy of TBI means that the use of this conditioning is essential even though it is limited by adverse effects: both acute and late toxicity. New methods of irradiation are desirable. In our Institution we have performed a phase II study (ClinicalTrials.gov NCT01665014) from 2012 for patients with multiple plasmocytoma. The TMI we use is a modified form of TBI. It seems to be especially appropriate for the treatment of neoplasms located mainly or only in bone marrow (multiple myeloma, acute leukemias). Limitation of irradiated volumes only to bones probably will reduce a toxicity of treatment. Currently there are no internationally agreed methodological guidelines for TMI. Also there are only few publications on TMI. The aim of this paper is to introduce the methodology of TMI used in our department.

Abstract

Allogenic and autologous hematopoietic stem cell transplantation (HSCT) is widely used for the treatment of manymyeloid and lymphoid malignancies. Conditioning precedes bone marrow transplantation. Chemotherapy alone or with radiotherapy (TBI — total bone marrow irradiation) are used to conditioning. The proven efficacy of TBI means that the use of this conditioning is essential even though it is limited by adverse effects: both acute and late toxicity. New methods of irradiation are desirable. In our Institution we have performed a phase II study (ClinicalTrials.gov NCT01665014) from 2012 for patients with multiple plasmocytoma. The TMI we use is a modified form of TBI. It seems to be especially appropriate for the treatment of neoplasms located mainly or only in bone marrow (multiple myeloma, acute leukemias). Limitation of irradiated volumes only to bones probably will reduce a toxicity of treatment. Currently there are no internationally agreed methodological guidelines for TMI. Also there are only few publications on TMI. The aim of this paper is to introduce the methodology of TMI used in our department.

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About this article
Title

Method of total marrow irradiation (TMI)

Journal

Nowotwory. Journal of Oncology

Issue

Vol 64, No 4 (2014)

Pages

314-320

Published online

2014-09-01

Page views

1302

Article views/downloads

5831

DOI

10.5603/NJO.2014.0052

Bibliographic record

Nowotwory. Journal of Oncology 2014;64(4):314-320.

Authors

Grzegorz Głowacki
Leszek Miszczyk
Krzysztof Ślosarek
Bożena Jochymek
Grzegorz Woźniak
Łukasz Matulewicz
Michał Radwan
Paulina Leszczyńska
Łukasz Dolla
Jacek Najda
Tomasz Krużel
Tomasz Czerw
Maria Saduś-Wojciechowska
Sebastian Giebel

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