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Long-term late toxicity analysis in patients with stage T1-T3N0 squamous cell laryngeal carcinoma treated with radical intent with conventional and accelerated schedules of radiotherapy
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Abstract
Aim of the study. The analysis of early and late toxicity was assessed comparing two schedules of irradiation — conventional fractionation (CF) and accelerated fractionation (AF). Our population of patients had squamous cell carcinoma of the larynx stage T1-T3N0M0. All were treated with radical intent.
Material and method. Patients treated 1995–1998 in the Centre of Oncology in Warsaw were separately analyzed in a phase III multicentre clinical trial. Patients were irradiated with Co-60, in the CF arm to a total dose of 66 Gy in 33 fractions with an overall treatment time of 45 days. In the AF arm the overall treatment time was 7 days shorter but the rest of parameters were not changed.
Results. A higher percentage of acute post-irradiation reactions was observed in patients who underwent AF. The early reactions settled down after termination in 5 to 8 weeks in both fractionation methods. There were no serious late post-irradiation complications stated in both group of patients examined.
Abstract
Aim of the study. The analysis of early and late toxicity was assessed comparing two schedules of irradiation — conventional fractionation (CF) and accelerated fractionation (AF). Our population of patients had squamous cell carcinoma of the larynx stage T1-T3N0M0. All were treated with radical intent.
Material and method. Patients treated 1995–1998 in the Centre of Oncology in Warsaw were separately analyzed in a phase III multicentre clinical trial. Patients were irradiated with Co-60, in the CF arm to a total dose of 66 Gy in 33 fractions with an overall treatment time of 45 days. In the AF arm the overall treatment time was 7 days shorter but the rest of parameters were not changed.
Results. A higher percentage of acute post-irradiation reactions was observed in patients who underwent AF. The early reactions settled down after termination in 5 to 8 weeks in both fractionation methods. There were no serious late post-irradiation complications stated in both group of patients examined.
About this articleTitle
Long-term late toxicity analysis in patients with stage T1-T3N0 squamous cell laryngeal carcinoma treated with radical intent with conventional and accelerated schedules of radiotherapy
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
224-229
Published online
2014-06-13
Page views
1055
Article views/downloads
2446
DOI
10.5603/NJO.2014.0036
Bibliographic record
Nowotwory. Journal of Oncology 2014;64(3):224-229.
Authors
Zbigniew Szutkowski
Andrzej Kawecki
Andrzej Jarząbski