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Research paper (original)
Published online: 2024-03-27
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Warthin tumors – risk factors, diagnostics, treatment

Katarzyna Kolary-Siekierska1, Anna Jałocha-Kaczka1, Piotr Niewiadomski1, Jarosław Miłoński1
Affiliations
  1. Department of Otolaryngology and Laryngological Oncology, Audiology and Phoniatrics, Medical University of Lodz, Lodz, Poland

open access

Ahead of print
Original articles – Tumor biology
Published online: 2024-03-27

Abstract

Introduction. Warthin's tumors are the second most common benign tumors of the salivary gland, located mainly in the parotid glands, sometimes bilaterally. The main risk factor is nicotine addiction. The aim of the study was to present our own experience in the diagnosis and treatment of salivary gland neoplasm and to analyze the risk factors for the development of Warthin tumors.

Materials and methods. The study group consisted of 55 patients operated on Warthin’s tumors (between 2009 and 2023). 55 control individuals with no Warthin tumors were recruited. The patients underwent a retrospective analysis of risk factors for head and neck cancer.

Results.  Warthin tumors patients reported salivary gland diseases, such as urolithiasis, inflammation, dry mouth, nicotine addiction, and chronic diseases, such as hypercholesterolemia. In 83% fine-needle aspiration biopsy (FNAB) of Warthin's tumor results were confirmed by the postoperative histopathological diagnosis. The therapy included extracapsular tumor removal, partial parotidectomy with preservation of the facial nerve, and removal of the submandibular gland. Postoperative complications were a cutaneous fistula and paresis of the marginal branch of the facial nerve.

Conclusions. The study confirmed that nicotine addiction (smoking duration and number of cigarettes smoked per day) was the main risk factor for the developing Warthin's tumor. An increase in BMI, hypercholesterolemia, salivary gland diseases, and dry mouth symptoms manifested Warthin’s tumors. FNAB, ultrasonography (USG) and computer tomography (CT) or magnetic resonance imaging (MRI) with contrast were essential in the diagnostics and planning therapeutic strategy. The main treatment used in the clinic was extracapsular tumor removal.

Abstract

Introduction. Warthin's tumors are the second most common benign tumors of the salivary gland, located mainly in the parotid glands, sometimes bilaterally. The main risk factor is nicotine addiction. The aim of the study was to present our own experience in the diagnosis and treatment of salivary gland neoplasm and to analyze the risk factors for the development of Warthin tumors.

Materials and methods. The study group consisted of 55 patients operated on Warthin’s tumors (between 2009 and 2023). 55 control individuals with no Warthin tumors were recruited. The patients underwent a retrospective analysis of risk factors for head and neck cancer.

Results.  Warthin tumors patients reported salivary gland diseases, such as urolithiasis, inflammation, dry mouth, nicotine addiction, and chronic diseases, such as hypercholesterolemia. In 83% fine-needle aspiration biopsy (FNAB) of Warthin's tumor results were confirmed by the postoperative histopathological diagnosis. The therapy included extracapsular tumor removal, partial parotidectomy with preservation of the facial nerve, and removal of the submandibular gland. Postoperative complications were a cutaneous fistula and paresis of the marginal branch of the facial nerve.

Conclusions. The study confirmed that nicotine addiction (smoking duration and number of cigarettes smoked per day) was the main risk factor for the developing Warthin's tumor. An increase in BMI, hypercholesterolemia, salivary gland diseases, and dry mouth symptoms manifested Warthin’s tumors. FNAB, ultrasonography (USG) and computer tomography (CT) or magnetic resonance imaging (MRI) with contrast were essential in the diagnostics and planning therapeutic strategy. The main treatment used in the clinic was extracapsular tumor removal.

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Keywords

Warthin tumor; salivary gland neoplasm; diagnostic; surgery treatment

About this article
Title

Warthin tumors – risk factors, diagnostics, treatment

Journal

Nowotwory. Journal of Oncology

Issue

Ahead of print

Article type

Research paper (original)

Published online

2024-03-27

Page views

20

Article views/downloads

11

Keywords

Warthin tumor
salivary gland neoplasm
diagnostic
surgery treatment

Authors

Katarzyna Kolary-Siekierska
Anna Jałocha-Kaczka
Piotr Niewiadomski
Jarosław Miłoński

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