Vol 73, No 6 (2023)
Pictures in Oncology
Published online: 2023-11-29

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A pregnant woman with invasive cervical carcinoma

Anna Dąbrowska1, Adrian Perdyan2, Bartosz K. Sobocki1, Jacek Rutkowski3
Nowotwory. Journal of Oncology 2023;73(6):405.


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Pictures in oncology

NOWOTWORY Journal of Oncology

2023, volume 73, number 6, 405

DOI: 10.5603/njo.96798

© Polskie Towarzystwo Onkologiczne

ISSN 0029–540X, e-ISSN: 2300-2115


A pregnant woman with invasive cervical carcinoma

Anna Dąbrowska1Adrian Perdyan2Bartosz K. Sobocki1Jacek Rutkowski3
1Student Scientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland
23P-Medicine Laboratory, Medical University of Gdansk, Gdansk, Poland
3Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland

How to cite:

Dąbrowska A, Perdyan A, Sobocki BK, Rutkowski J. A pregnant woman with invasive cervical carcinoma. NOWOTWORY J Oncol 2023; 73: 405.

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

A 34-year-old woman in the 24th week of her third pregnancy was admitted to the Department of Gynecology and Obstetrics after a few episodes of short, vaginal bleeding, beginning in the 18th week, which raised a suspicion of cervical cancer. A routine cytology was performed during the 12th week of pregnancy (the first in the past 7 years), which yielded an inconclusive result. Therefore, it was recommended to extend the diagnostics. At admission, a gynecological examination showed uterine cervix shape deformation and immobilization, with visible nodular lesion on the cervical surface, confirmed as invasive squamous-cell carcinoma. The MRI of the pelvis and abdomen showed a circular neoplasm located in the upper part of the cervical canal, with a tumor measuring 37x46x48 mm (fig. 1). On the right side, the tumor infiltrates the parametria. Pelvical and abdominal lymphadenopathy were not observed, as well as distant metastases (stage IIB according to the FIGO Classification [1]). Therefore, the patient was qualified for neoadjuvant chemotherapy. The patient received three cycles of cisplatin and paclitaxel (the first cycle in the 24th week of pregnancy) in standard doses based on body weight, taking into account the weight of the fetus. The pregnancy ended with a planned caesarean section in the 34th week. The patient gave birth to a daughter (Apgar score of 9) with no complications during delivery and confinement. The post-chemotherapy MRI revealed a partial regression of the primary lesion to 25x14x14 mm. During confinement, the patient received teleradiotherapy for the pelvic region (45 Gy/25 fractions) with concomitant weekly cisplatin chemotherapy (40 mg/m2) and a high dose rate (HDR) brachytherapy (28.5 Gy/4 fractions) (Ir 192, 3D planning). Complete remission in clinical and radiological control was observed 3 months after treatment completion. After 48 months, the patient’s condition remains excellent, with no signs of relapse.

Figure 1. MRI before (A, B) and after (C, D) neoadjuvant chemotherapy


  1. Bhatla N, Aoki D, Sharma DN, et al. Cancer of the cervix uteri. Int J Gynaecol Obstet. 2018; 143 Suppl 2(Suppl 1): 2236, doi: 10.1002/ijgo.12611, indexed in Pubmed: 30306584.