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Interactions between Notch and Matrix metalloproteinases: the role in cancer
, 1
Affiliations- Department of Biotechnology, Dayananda Sagar College of Engineering, Bangalore, India
- Visvesvaraya Technological University, Karnataka, India
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Abstract
Notch has its importance in the development and maintenance of cells and tissues. Either gain or loss of notch signalling causes a wide range of abnormalities including cancer. To activate Notch signalling, the notch ligand must be processed by the family of proteases, ADAMs. Until recently, exclusively in a cancer context, a class of proteases, Matrix metalloproteinases (MMPs) were known to cleave notch and trigger downstream signalling. Notch was found to regulate the expression of Matrix metalloproteinases (MMPs) through crosstalk. Studies have revealed that interactions between notch and MMPs are associated with aggressive cancer traits such as invasion, metastasis, angiogenesis, and endothelial mesenchymal transition. In this review, we resummarise the studies which reveal the Notch-MMP interactions that have provided new perceptions into the mechanisms behind Notch-mediated aggressiveness in cancers.
Abstract
Notch has its importance in the development and maintenance of cells and tissues. Either gain or loss of notch signalling causes a wide range of abnormalities including cancer. To activate Notch signalling, the notch ligand must be processed by the family of proteases, ADAMs. Until recently, exclusively in a cancer context, a class of proteases, Matrix metalloproteinases (MMPs) were known to cleave notch and trigger downstream signalling. Notch was found to regulate the expression of Matrix metalloproteinases (MMPs) through crosstalk. Studies have revealed that interactions between notch and MMPs are associated with aggressive cancer traits such as invasion, metastasis, angiogenesis, and endothelial mesenchymal transition. In this review, we resummarise the studies which reveal the Notch-MMP interactions that have provided new perceptions into the mechanisms behind Notch-mediated aggressiveness in cancers.
Keywords
angiogenesis; epithelial mesenchymal transition; invasion; matrix metalloproteinase; non-canonical notch signalling
About this articleTitle
Interactions between Notch and Matrix metalloproteinases: the role in cancer
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Published online
2023-10-13
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67
Article views/downloads
75
DOI
Keywords
angiogenesis
epithelial mesenchymal transition
invasion
matrix metalloproteinase
non-canonical notch signalling
Authors
Jeeja Hernole
Rajeswari Narayanappa