open access
Dose estimation in patients treated with radiotherapy for SARS-COVID disease based on EPID measurement
Affiliations- National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
- Varian Medical Systems, Warsaw, Poland
open access
Abstract
Introduction.COVID radiotherapy requires performance of all radiotherapy (RT) procedures during one site visit due to the infectious nature of the disease. The aim of the study was to develop methods of estimating the delivered dose based on electronic portal image device (EPID) signal during treatment.
Material and methods.Electronic portal image device signal was measured as a function of the phantom dose. The dose in 14 COVID patients was estimated for two X6MV beams.
Results.The method allows to estimate dose in phantom with uncertainty of 12%. In this case, a systematic error was reported. Therefore, coefficients for clinical data were calculated and used to determine the dose in patients. The mean difference between the dose calculated and the dose measured for the 14 patients was 1%, but the uncertainty of this method was estimated as ±6%
Conclusions.The proposed method may be useful in clinical practice as in vivo method. However, due to high uncertainty, it should be dedicated to the detection of “big” errors.
Abstract
Introduction.COVID radiotherapy requires performance of all radiotherapy (RT) procedures during one site visit due to the infectious nature of the disease. The aim of the study was to develop methods of estimating the delivered dose based on electronic portal image device (EPID) signal during treatment.
Material and methods.Electronic portal image device signal was measured as a function of the phantom dose. The dose in 14 COVID patients was estimated for two X6MV beams.
Results.The method allows to estimate dose in phantom with uncertainty of 12%. In this case, a systematic error was reported. Therefore, coefficients for clinical data were calculated and used to determine the dose in patients. The mean difference between the dose calculated and the dose measured for the 14 patients was 1%, but the uncertainty of this method was estimated as ±6%
Conclusions.The proposed method may be useful in clinical practice as in vivo method. However, due to high uncertainty, it should be dedicated to the detection of “big” errors.
Keywords
SARS-COVID; EPID; fluence map; QA; in-vivo dosimetry
About this articleTitle
Dose estimation in patients treated with radiotherapy for SARS-COVID disease based on EPID measurement
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
67-73
Published online
2022-02-14
Page views
5111
Article views/downloads
458
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2022;72(2):67-73.
Keywords
SARS-COVID
EPID
fluence map
QA
in-vivo dosimetry
Authors
Krzysztof Ślosarek
Tomasz Rutkowski
Adam Gądek
Łukasz Sroka
Łukasz Dolla
Roman Rutkowski
Jerzy Jaroszkiewicz
References (23)- Sroka Ł, Gądek A, Dolla Ł, et al. Przeciwzapalne napromienianie płuc chorych na COVID-19. Inżynier i Fizyk Medyczny. 2021; 10(2).
- Ślosarek K, Gądek A, Sroka Ł, et al. Lung volume irradiation procedures in patients with pneumonia during COVID-19 infection – physical aspects of treatment planning and dosimetry. Nowotwory. Journal of Oncology. 2021; 71(4): 238–242.
- van Elmpt W, McDermott L, Nijsten S, et al. A literature review of electronic portal imaging for radiotherapy dosimetry. Radiother Oncol. 2008; 88(3): 289–309.
- Celi S, Costa E, Wessels C, et al. EPID based in vivo dosimetry system: clinical experience and results. J Appl Clin Med Phys. 2016; 17(3): 262–276.
- van Elmpt W, Nijsten S, Mijnheer B, et al. The next step in patient-specific QA: 3D dose verification of conformal and intensity-modulated RT based on EPID dosimetry and Monte Carlo dose calculations. Radiother Oncol. 2008; 86(1): 86–92.
- Klimas A, Grządziel A, Plaza D, et al. EPID – a useful interfraction QC tool. Polish Journal of Medical Physics and Engineering. 2019; 25(4): 221–228.
- Kruszyna-Mochalska M. EPID-based daily verification of reproducibility of patients' irradiation with IMRT plans. Rep Pract Oncol Radiother. 2018; 23(5): 309–314.
- Ślosarek K, Plaza D, Nas A, et al. Portal dosimetry in radiotherapy repeatability evaluation. J Appl Clin Med Phys. 2021; 22(1): 156–164.
- van Elmpt W, Petit S, De Ruysscher D, et al. 3D dose delivery verification using repeated cone-beam imaging and EPID dosimetry for stereotactic body radiotherapy of non-small cell lung cancer. Radiother Oncol. 2010; 94(2): 188–194.
- Slosarek K, Szlag M, Bekman B, et al. EPID in vivo dosimetry in RapidArc technique. Rep Pract Oncol Radiother. 2010; 15(1): 8–14.
- McDermott LN, Wendling M, Nijkamp J, et al. 3D in vivo dose verification of entire hypo-fractionated IMRT treatments using an EPID and cone-beam CT. Radiother Oncol. 2008; 86(1): 35–42.
- Miri N, Keller P, Zwan BJ, et al. EPID-based dosimetry to verify IMRT planar dose distribution for the aS1200 EPID and FFF beams. J Appl Clin Med Phys. 2016; 17(6): 292–304.
- Wendling M, Louwe RJW, McDermott LN, et al. Accurate two-dimensional IMRT verification using a back-projection EPID dosimetry method. Med Phys. 2006; 33(2): 259–273.
- van Zijtveld M, Dirkx MLP, de Boer HCJ, et al. 3D dose reconstruction for clinical evaluation of IMRT pretreatment verification with an EPID. Radiother Oncol. 2007; 82(2): 201–207.
- Lim SB, Zwan BJ, Lee D, et al. A novel quality assurance procedure for trajectory log validation using phantom-less real-time latency corrected EPID images. J Appl Clin Med Phys. 2021; 22(3): 176–185.
- Alves VG, Ahmed M, Aliotta E, et al. An error detection method for real-time EPID-based treatment delivery quality assurance. Med Phys. 2021; 48(2): 569–578.
- McCowan PM, Rickey DW, Rowshanfarzad P, et al. An investigation of gantry angle data accuracy for cine-mode EPID images acquired during arc IMRT. J Appl Clin Med Phys. 2014; 15(1): 4507.
- Defoor DL, Vazquez-Quino LA, Mavroidis P, et al. Anatomy-based, patient-specific VMAT QA using EPID or MLC log files. J Appl Clin Med Phys. 2015; 16(3): 5283.
- van Zijtveld M, Dirkx MLP, de Boer HCJ, et al. Dosimetric pre-treatment verification of IMRT using an EPID; clinical experience. Radiother Oncol. 2006; 81(2): 168–175.
- Grządziel A, Smolińska B, Rutkowski R, et al. EPID dosimetry – configuration and pre-treatment IMRT verification. Reports of Practical Oncology & Radiotherapy. 2007; 12(6): 307–312.
- Essers M, Mijnheer B. In vivo dosimetry during external photon beam radiotherapy. Int J Radiat Biol. 1999; 43(2): 245–259.
- Calabrese EJ, Dhawan G. How radiotherapy was historically used to treat pneumonia: could it be useful today? Yale J Biol Med. 2013; 86(4): 555–570.
- Arenas M, Sabater S, Hernández V, et al. Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved. Strahlenther Onkol. 2012; 188(11): 975–981.