Vol 71, No 5 (2021)
Review paper
Published online: 2021-10-13
Significance of genetic and radiological examinations in diagnosis and therapy of brain glioma in adult patients
Nowotwory. Journal of Oncology 2021;71(5):328-334.
Abstract
Molecular and imaging studies are applied along with histopathology in diagnosis and differential diagnosis of brain gliomas and they enable personalised clinical management. With knowledge of the patient’s clinical condition, a decision whether to observe the patient or proceed to immediate surgical treatment is made based on imaging results. On the other hand, knowledge of molecular predictive markers allows optimisation of chemotherapeutic decisions, e.g., introduction of personalised therapy (application of such drugs as temozolomide, bevacizumab, vemurafenib, dabrafenib and trametinib).
Keywords: brain gliomaspersonalised medicinemolecular diagnosticsimaging diagnosticsMRIperfusion MRIMR spectroscopydiffusion tensor MRIfMRItemozolomidebevacizumab
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