Vol 66, No 1 (2016)
Review paper
Published online: 2016-04-07
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Tumour cell migration and invasion: an impact of cell plasticity and extracellular matrix on metastasis
Nowotwory. Journal of Oncology 2016;66(1):45-52.
Abstract
Migratory and invasive potential of the cell is determined by the type of a tissue from which the cell derives. However, in case of neoplastic cells they display some plasticity of a phenotype which enables changes in the mode of migration. These transitions may influence the metastatic potential of the tumour. Processes described vitally depend on the tumour microenvironment and may be regulated by the dynamic of the extracellular matrix alterations.