open access

Vol 66, No 1 (2016)
Research paper (original)
Published online: 2016-04-07
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Classical variant of infiltrating lobular breast cancer seen in the Oncology Centre in Krakow: clinical characteristics, results of therapy and prognostic factors in patients treated 1980–2005

Piotr Skotnicki, Łukasz Wohadlo, Beata Sas-Korczyńska, Marian Reinfuss, Jerzy W. Mituś, Tomasz Walasek
DOI: 10.5603/NJO.2016.0003
·
Nowotwory. Journal of Oncology 2016;66(1):26-34.

open access

Vol 66, No 1 (2016)
Original article
Published online: 2016-04-07

Abstract

Introduction. Infiltrating lobular breast cancer (ILC) accounts for approximately 5–10% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for classical variant of ILC (C-ILC).

Material and methods. The analysis was performed in group of 220 patients with C-ILC treated between 1980 and 2005. Stage I or II cancer was found in 67.7% patients, and in 172 patients (78.2%) the tumour diameter was lower than 5 cm (78.2%), 121 patients (55%) did not develop lymph node metastases. Immunohistochemical analysis showed estrogen receptor positivity (80.9%), progesterone receptor positivity (72.7%) and expression of HER2/neu (3.7%). The multifocal changes were present in 14 cases (6.4%). All patients received surgical treatment: mastectomy (189 — 85.9%) or breast-conserving therapy (31 — 14.1%). The adiuvant treatment consisted of radiotherapy (141 patients — 64.1%), chemotherapy (35 patients — 15.9%) and hormonotherapy (120 patients — 54.5%).

Results. The 10-year disease-free survival rate was 65%. Multivariate analysis showed that an independent statistically significant prognostic factor was microscopic status of axillary lymph nodes. During follow-up the development of breast cancer in the second breast was observed in 19 patients ( 8.6%) and 55 patients (25%) developed distant metastases.

Conclusions. The C-ILC has some specific clinico-pathological characteristics and it is possible to perform breast- -conserving treatment in these cases. The negative prognostic factor is the presence of lymph node metastases.  

Abstract

Introduction. Infiltrating lobular breast cancer (ILC) accounts for approximately 5–10% of all breast cancer types. The purpose of this study is to present the clinico-pathological characteristics and treatment results in patients treated for classical variant of ILC (C-ILC).

Material and methods. The analysis was performed in group of 220 patients with C-ILC treated between 1980 and 2005. Stage I or II cancer was found in 67.7% patients, and in 172 patients (78.2%) the tumour diameter was lower than 5 cm (78.2%), 121 patients (55%) did not develop lymph node metastases. Immunohistochemical analysis showed estrogen receptor positivity (80.9%), progesterone receptor positivity (72.7%) and expression of HER2/neu (3.7%). The multifocal changes were present in 14 cases (6.4%). All patients received surgical treatment: mastectomy (189 — 85.9%) or breast-conserving therapy (31 — 14.1%). The adiuvant treatment consisted of radiotherapy (141 patients — 64.1%), chemotherapy (35 patients — 15.9%) and hormonotherapy (120 patients — 54.5%).

Results. The 10-year disease-free survival rate was 65%. Multivariate analysis showed that an independent statistically significant prognostic factor was microscopic status of axillary lymph nodes. During follow-up the development of breast cancer in the second breast was observed in 19 patients ( 8.6%) and 55 patients (25%) developed distant metastases.

Conclusions. The C-ILC has some specific clinico-pathological characteristics and it is possible to perform breast- -conserving treatment in these cases. The negative prognostic factor is the presence of lymph node metastases.  

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About this article
Title

Classical variant of infiltrating lobular breast cancer seen in the Oncology Centre in Krakow: clinical characteristics, results of therapy and prognostic factors in patients treated 1980–2005

Journal

Nowotwory. Journal of Oncology

Issue

Vol 66, No 1 (2016)

Article type

Research paper (original)

Pages

26-34

Published online

2016-04-07

DOI

10.5603/NJO.2016.0003

Bibliographic record

Nowotwory. Journal of Oncology 2016;66(1):26-34.

Authors

Piotr Skotnicki
Łukasz Wohadlo
Beata Sas-Korczyńska
Marian Reinfuss
Jerzy W. Mituś
Tomasz Walasek

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