open access

Vol 65, No 6 (2015)
Oncological debates
Published online: 2016-02-05
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Overuse of granulocyte colony stimulating factors in systemic cancer therapy

Jan Walewski
DOI: 10.5603/NJO.2015.0108
·
Nowotwory. Journal of Oncology 2015;65(6):529-534.

open access

Vol 65, No 6 (2015)
Oncological debates
Published online: 2016-02-05

Abstract

The use of granulopoietic agents has become widespread in cancer patients receiving chemotherapy, and a number of reliable population-based studies suggest major deviations from the international evidence-based guidelines. In effect, the growth factors are overused or not used when clinically indicated. In addition, recent randomised studies in patients with aggressive lymphoma provide evidence against the benefit of once commonly believed tactics of dose-dense chemotherapy made possible by the use of G-CSF. We review of contributions implicating an overuse or underuse of G-CSF in oncology practice.

Abstract

The use of granulopoietic agents has become widespread in cancer patients receiving chemotherapy, and a number of reliable population-based studies suggest major deviations from the international evidence-based guidelines. In effect, the growth factors are overused or not used when clinically indicated. In addition, recent randomised studies in patients with aggressive lymphoma provide evidence against the benefit of once commonly believed tactics of dose-dense chemotherapy made possible by the use of G-CSF. We review of contributions implicating an overuse or underuse of G-CSF in oncology practice.

Get Citation
About this article
Title

Overuse of granulocyte colony stimulating factors in systemic cancer therapy

Journal

Nowotwory. Journal of Oncology

Issue

Vol 65, No 6 (2015)

Pages

529-534

Published online

2016-02-05

DOI

10.5603/NJO.2015.0108

Bibliographic record

Nowotwory. Journal of Oncology 2015;65(6):529-534.

Authors

Jan Walewski

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