Preoperative chemotherapy in the colorectal cancer patients with synchronous metastases to the liver. A vote for YES

Abstract

The increasing effectiveness of chemotherapy (cht) has led to a rise in interest in preoperative neoadjuvant treatment preceding resection of colorectal metastases. Preoperative chemotherapy is often undertaken as a method of natural evaluation of the progress of metastases before starting metastasectomy, in particular in patients with synchronous liver metastases. This method also has the potential of reducing potentially unresectable metastases and allowing for their safe resection. Optimal selection of patients, the choice of treatment regimen, and timing as well as the most beneficial method of integrating chemotherapy with the surgery has not been defined.