open access

Vol 68, No 5-6 (2018)
Case report
Published online: 2019-05-07
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Local therapy for radiotherapy-associated angiosarcoma of the breast after organ-sparing treatment of primary breast cancer patients. A report of two cases and review of therapeutic options

Krystyna Serkies, Zuzanna Baczkowska-Waliszewska, Agata Kacprowska, Marcin Sinacki
DOI: 10.5603/2018.0043
·
Nowotwory. Journal of Oncology 2018;68(5-6):273-276.

open access

Vol 68, No 5-6 (2018)
Case report
Published online: 2019-05-07

Abstract

Radiotherapy-associated angiosarcoma of the breast in breast cancer patients is a rare, poor-prognosis malignancy. Surgical resection with mastectomy is the standard local treatment for this disease. We present two cases of localized secondary angiosarcoma of the breast following breast-conserving therapy for early breast cancer, who underwent salvage mastectomy with R0 resection, followed by chemotherapy in one case. Both patients developed thoracic wall recurrence, and received palliative radio- and chemotherapy. In 23 months after being diagnosed with angiosarcoma, they died of uncontrolled local and distant disease. Our cases confirmed the high risk of local failure after salvage mastectomy due to radiotherapy-induced angiosarcoma. Based on literature, better local control might be achieved with more aggressive surgical approach with excision of all irradiated skin and soft tissue, and with re-irradiation.

Abstract

Radiotherapy-associated angiosarcoma of the breast in breast cancer patients is a rare, poor-prognosis malignancy. Surgical resection with mastectomy is the standard local treatment for this disease. We present two cases of localized secondary angiosarcoma of the breast following breast-conserving therapy for early breast cancer, who underwent salvage mastectomy with R0 resection, followed by chemotherapy in one case. Both patients developed thoracic wall recurrence, and received palliative radio- and chemotherapy. In 23 months after being diagnosed with angiosarcoma, they died of uncontrolled local and distant disease. Our cases confirmed the high risk of local failure after salvage mastectomy due to radiotherapy-induced angiosarcoma. Based on literature, better local control might be achieved with more aggressive surgical approach with excision of all irradiated skin and soft tissue, and with re-irradiation.

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Keywords

breast cancer; secondary malignancies; radiotherapy; organ-sparing treatment; angiosarcoma

About this article
Title

Local therapy for radiotherapy-associated angiosarcoma of the breast after organ-sparing treatment of primary breast cancer patients. A report of two cases and review of therapeutic options

Journal

Nowotwory. Journal of Oncology

Issue

Vol 68, No 5-6 (2018)

Article type

Case report

Pages

273-276

Published online

2019-05-07

Page views

360

Article views/downloads

614

DOI

10.5603/2018.0043

Bibliographic record

Nowotwory. Journal of Oncology 2018;68(5-6):273-276.

Keywords

breast cancer
secondary malignancies
radiotherapy
organ-sparing treatment
angiosarcoma

Authors

Krystyna Serkies
Zuzanna Baczkowska-Waliszewska
Agata Kacprowska
Marcin Sinacki

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