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Molecular markers used in breast cancer diagnosis — current practice and future perspectives
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Abstract
Breast cancer is the most frequently diagnosed cancer among women and a leading cause of cancer-related death. Despite many available diagnostic tools and techniques, tumor heterogeneity and molecular diversity of breast cancer tumors require new biomarkers in clinical practice. A potential diagnostic test can be built based on few biomarkers. Those biomarkers may not be specific and sensitive enough to be a single diagnostic tool, but might be useful as a set of biomarkers e.g. CEA, CA15-3, MammaPrint®, HER2 and BRCA1, 2. The second group of potential biomarkers are microRNAs. Changes in miRNA and altered genes expression may contribute to the development of breast cancer and metastases. Integration of proteomics, genomics, and metabolomics data is necessary to discover a new panel of biomarkers.
Abstract
Breast cancer is the most frequently diagnosed cancer among women and a leading cause of cancer-related death. Despite many available diagnostic tools and techniques, tumor heterogeneity and molecular diversity of breast cancer tumors require new biomarkers in clinical practice. A potential diagnostic test can be built based on few biomarkers. Those biomarkers may not be specific and sensitive enough to be a single diagnostic tool, but might be useful as a set of biomarkers e.g. CEA, CA15-3, MammaPrint®, HER2 and BRCA1, 2. The second group of potential biomarkers are microRNAs. Changes in miRNA and altered genes expression may contribute to the development of breast cancer and metastases. Integration of proteomics, genomics, and metabolomics data is necessary to discover a new panel of biomarkers.
Keywords
breast cancer; biomarker; molecular biomarker; diagnostics; early detection
About this articleTitle
Molecular markers used in breast cancer diagnosis — current practice and future perspectives
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
259-267
Published online
2019-05-07
Page views
573
Article views/downloads
1674
DOI
10.5603/2018.0041
Bibliographic record
Nowotwory. Journal of Oncology 2018;68(5-6):259-267.
Keywords
breast cancer
biomarker
molecular biomarker
diagnostics
early detection
Authors
Anna Walaszczyk
Dorota Gabryś