open access
The retrospective analysis of recurrent salivary gland cancer after surgery and adjuvant radio- or chemoradiotherapy
open access
Abstract
Introduction. The aim of the study was to analyse the survival and progression rates in patients with recurrent salivary gland cancer after surgery and adjuvant radio- or chemoradiotherapy. Material and methods. The study included 43 patients treated in 2006–2016 and evaluated in terms of PFS and OS. Results. The 6-, 12- and 24-month OS rates were: 51%, 41%, and 14%, respectively, while the 6-, 12- and 24-month PFS rates were: 44%, 27%, and 14%, respectively. Any treatment improves OS and PFS, with surgery having the greatest effect on improving PFS, followed by chemotherapy and radiotherapy. A multivariate analysis has shown that predictors of PFS are: irradiated volume and radiation technique, while irradiated volume is the predictor of OS. Conclusions. Prognosis in patients with recurrent gland cancer is poor and does not depend on the type of relapse, but rather on further management.
Abstract
Introduction. The aim of the study was to analyse the survival and progression rates in patients with recurrent salivary gland cancer after surgery and adjuvant radio- or chemoradiotherapy. Material and methods. The study included 43 patients treated in 2006–2016 and evaluated in terms of PFS and OS. Results. The 6-, 12- and 24-month OS rates were: 51%, 41%, and 14%, respectively, while the 6-, 12- and 24-month PFS rates were: 44%, 27%, and 14%, respectively. Any treatment improves OS and PFS, with surgery having the greatest effect on improving PFS, followed by chemotherapy and radiotherapy. A multivariate analysis has shown that predictors of PFS are: irradiated volume and radiation technique, while irradiated volume is the predictor of OS. Conclusions. Prognosis in patients with recurrent gland cancer is poor and does not depend on the type of relapse, but rather on further management.
Keywords
salivary gland cancer; toxicity; recurrences; radiotherapy; chemoradiotherapy
About this articleTitle
The retrospective analysis of recurrent salivary gland cancer after surgery and adjuvant radio- or chemoradiotherapy
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Research paper (original)
Pages
245-252
Published online
2019-05-07
Page views
327
Article views/downloads
437
DOI
10.5603/2018.0039
Bibliographic record
Nowotwory. Journal of Oncology 2018;68(5-6):245-252.
Keywords
salivary gland cancer
toxicity
recurrences
radiotherapy
chemoradiotherapy
Authors
Izabela Kordzińska-Cisek
Ludmiła Grzybowska-Szatkowska