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open access

Vol 57, No 1 (2023)
Review Article
Submitted: 2022-12-21
Accepted: 2023-01-09
Published online: 2023-02-02
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Navigating the landscape of COVID-19 for Multiple Sclerosis patients and clinicians

Klara Dyczkowska1, Alicja Kalinowska-Łyszczarz2
DOI: 10.5603/PJNNS.a2023.0004
·
Pubmed: 36727546
·
Neurol Neurochir Pol 2023;57(1):90-100.
Affiliations
  1. Heliodor Swiecicki University Hospital in Poznan, Poznan, Poland
  2. Department of Neurology, Division of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, Poland

open access

Vol 57, No 1 (2023)
REVIEW ARTICLES — LEADING TOPIC
Submitted: 2022-12-21
Accepted: 2023-01-09
Published online: 2023-02-02

Abstract

The purpose of this literature review was to summarise relevant findings regarding the clinical management of multiple sclerosis (MS) in the COVID-19 pandemic, with the focus on patient risks, and the implications of disease-modifying treatment, both on COVID-19 severity and on the response to the SARS-CoV-2 vaccinations. Although MS per se does not seem to put patients at risk for more severe COVID-19, alongside the risk factors known to apply to the general population, progressive disease course, higher disability status, and B-cell depleting therapies may all negatively affect infection severity. The question of COVID-19 sequelae in patients with MS (pwMS) remains unresolved, challenging researchers to further explore this area. The safety profile of COVID-19 vaccinations in pwMS is similar to that of the general population. The efficacy of the vaccination might be affected by B-cell depletion, as well as by S1PR-modulating medications that attenuate humoral responses to the COVID-19 vaccination. Future research should focus on gathering evidence regarding the clinical course of MS following COVID-19 infection and vaccination in larger studies, as well as on establishing the safest and most efficient schedule of COVID-19 vaccination in pwMS on cell-depleting therapies.

Abstract

The purpose of this literature review was to summarise relevant findings regarding the clinical management of multiple sclerosis (MS) in the COVID-19 pandemic, with the focus on patient risks, and the implications of disease-modifying treatment, both on COVID-19 severity and on the response to the SARS-CoV-2 vaccinations. Although MS per se does not seem to put patients at risk for more severe COVID-19, alongside the risk factors known to apply to the general population, progressive disease course, higher disability status, and B-cell depleting therapies may all negatively affect infection severity. The question of COVID-19 sequelae in patients with MS (pwMS) remains unresolved, challenging researchers to further explore this area. The safety profile of COVID-19 vaccinations in pwMS is similar to that of the general population. The efficacy of the vaccination might be affected by B-cell depletion, as well as by S1PR-modulating medications that attenuate humoral responses to the COVID-19 vaccination. Future research should focus on gathering evidence regarding the clinical course of MS following COVID-19 infection and vaccination in larger studies, as well as on establishing the safest and most efficient schedule of COVID-19 vaccination in pwMS on cell-depleting therapies.

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Keywords

multiple sclerosis, COVID-19, SARS-CoV-2, COVID-19 vaccination, disease-modifying therapy

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About this article
Title

Navigating the landscape of COVID-19 for Multiple Sclerosis patients and clinicians

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 57, No 1 (2023)

Article type

Review Article

Pages

90-100

Published online

2023-02-02

Page views

2965

Article views/downloads

605

DOI

10.5603/PJNNS.a2023.0004

Pubmed

36727546

Bibliographic record

Neurol Neurochir Pol 2023;57(1):90-100.

Keywords

multiple sclerosis
COVID-19
SARS-CoV-2
COVID-19 vaccination
disease-modifying therapy

Authors

Klara Dyczkowska
Alicja Kalinowska-Łyszczarz

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