Vol 56, No 4 (2022)
Letter to the Editors
Published online: 2022-03-21

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Paroxysmal hemicrania or short-lasting unilateral neuralgiform headache attacks with trigeminal neuralgia – functional neuroimaging findings

Izabela Domitrz1, Ewa Piątkowska-Janko23, Jacek J. Rożniecki4, Nikodem Hryniewicz3, Piotr Bogorodzki23
Pubmed: 35312033
Neurol Neurochir Pol 2022;56(4):381-383.

Abstract

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LETTER TO THE EDITORS

Neurologia i Neurochirurgia Polska

Polish Journal of Neurology and Neurosurgery

2022, Volume 56, no. 4, pages: 381–383

DOI: 10.5603/PJNNS.a2022.0025

Copyright © 2022 Polish Neurological Society

ISSN: 0028-3843, e-ISSN: 1897-4260

Paroxysmal hemicrania or short-lasting unilateral neuralgiform headache attacks with trigeminal neuralgia — functional neuroimaging findings

Izabela Domitrz1Ewa Piątkowska-Janko23Jacek J. Rożniecki4Nikodem Hryniewicz3Piotr Bogorodzki23
1Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, Poland
2Faculty of Electronics and Information Technology, Institute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, Warsaw, Poland
3Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland
4Department of Neurology, Stroke and Neurorehabilitation, Medical University of Lodz, Poland

Address for correspondence: Izabela Domitrz, Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, 80 Cegłowska Str., 01–809 Warsaw, Poland; e-mail: izabela.domitrz@wum.edu.pl

Received: 19.02.2022 Accepted: 04.03.2022 Early publication date: 21.03.2022

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Key words: trigeminal neuralgia (TN), trigeminal-autonomic cephalalgias (TACs), paroxysmal hemicrania (PH), short-lasting unilateral neuralgiform headache (SUNH), cluster headache (CH), hemicrania continua (HC), fMRI
(Neurol Neurochir Pol 2022; 56 (4): 381–383)

To the Editors

Headaches with severe, unilateral attacks in orbital/supraorbital/temporal locations with ipsilateral autonomic symptoms are defined in the ICHD-3 [1] as trigeminal-autonomic cephalalgias (TACs). Other cluster headaches, with shorter attacks, are recognised as paroxysmal hemicrania (PH) characterised by several attacks per day, each lasting 2–30 min, also associated with ipsilateral autonomic symptoms responding absolutely to indomethacin, or short-lasting unilateral neuralgiform headaches (SUNH) characterised by similar attacks with autonomic symptoms lasting 1–600 s [2]. Trigeminal neuralgia (TN) attacks last between one second and two minutes without autonomic symptoms.

There is a special category for patients with overlapping features of PH, SUNH and TN, known since 2003 as ‘TAC-tic syndrome’, of which there are only a few case reports [3].

We present the case of a patient with a headache which met ICHD-3 criteria of PH, SUNCT and TN with fMRI (functional Magnetic Resonanse Imaging) findings during painful and pain-free periods. A 39-year-old-woman, without any history of headaches, presented with very severe facial pain on the right side, with typical for autonomic cephalalgias autonomic symptoms of two months’ duration. The headache presented as unilateral attacks of pain in the right cheek described as an ‘electric current’ radiating from the second upper tooth to the eye, lasting from 5 s to 30 min, many times a day, along with constant chronic daily pain in the right eye. The attacks of pain radiating through the cheek to the eye were associated with ipsilateral lacrimation, nasal congestion, rhinorrhea, facial and forehead sweating, miosis, ptosis, and eyelid oedema. During the attacks, she was restless and agitated. In 2012, she was diagnosed with secondary TN as a manifestation of dental treatment complication. In 2018, another kind of headache happened on the same side, with ipsilateral autonomic symptoms overlapping the existing TN. The attacks lasted 5–1,800 s and at least 10 times per day. The headaches could have been classified as PH just as easily as SUNH. They responded well to indomethacin — the patient initially received treatment with indomethacin at a dose of 150 mg twice a day, and within three days she was completely free from headaches, thus fulfilling the criteria of PH. The dose of indomethacin was decreased to 75 mg. After some months, the headaches recurred with moderate severity, but on this occasion indomethacin (up to 300 mg per day) was ineffective. Therefore treatment with lamotrigine was initiated, starting with a dose of 25 mg/day and increasing to 100 mg twice a day with a very good outcome. In the above-described patient we finally made the diagnosis of PH-SUNH and TN, calling it PH/SUNH-tic syndrome. We performed fMRI (functional neuroimaging) during the painful period i.e. before initiating indomethacin treatment, and six months later i.e. in the pain-free period, without headaches and without autonomic symptoms. We chose regions called the Pain Matrix, and compared BOLD signal changes in fMRI in these regions during painful and pain-free periods (Tab. 1 and Fig. 1).

Table 1. Spatial localisation of pain activated (p < 0.05 Family-Wise Error (FWE) rate) voxel clusters (k > 4): as described in Talairach Daemon and Broadman atlases, Montreal Neurological Institute (MNI) spatial coordinates of maximum scores and corresponding T score

Activation during pain period (without treatment)

TD brain region

Brodmann area

MNI coordinates (x, y, z)

T-value

Cerebellum right

18, –73, –19

9.85

Inferior frontal gyrus LH

BA 44

–60, 8, 23

8.60

Postcentral gyrus LH

Left — PrimSensory (S1)

–63, –19, 23

8.34

Insular LH

–42, 8, 5

6.62

Postcentral gyrus RH

BA 3

60, –22, 38

6.34

Activation during pain-free period — without headaches and without autonomic symptoms

TD brain region

Brodmann area

MNI coordinates (x, y, z)

T-value

Precentral gyrus LH

BA4/BA6

–60, –4, 41

7.89

Precentral gyrus RH

BA 6

51, –4, 32

7.59

Superior occipital gyrus LH

BA 19

–6, –91, 41

7.29

Supramarginal gyrus RH

BA 42

66, –37, 20

7.24

Figure 1. (A) Blood oxygen level-dependent (BOLD) signal comparison for painful and pain-free periods. A) pain-activated clusters (FWE < 0.05) overlaid on T1 image sagittal slice (x = 60, x = 44, x = 0, x = –60); (B) BOLD percentage signal change (PSCH) in Pain Matrix bilateral regions: thalamus, insular cortex (IC), primary and secondary somatosensory cortex (SI and SII), anterior prefrontal cortex (PFC), and cingulate cortex (ACC). Bar plots with solid fillings show statistically significant (FDR < 0.05) signal change in relation to rest period, either increases (red) or decreases (blue); LH — left hemisphere; RH — right hemisphere

Successful treatment of the PH/SUNH attacks was related to an increase in the neuronal activity in the brain, with a decrease in the number of activations in the Pain Matrix. The patient had typical clinical features of TACs — PH and SUNH, as well as TN. The initial response to indomethacin was meaningful, but at the recurrence of headaches this was lost and replaced by a good effect following lamotrigine.

Our report presents a very rare headache with investigation using fMRI in painful and pain-free periods for the first time. We found a decrease of activation in all Pain Matrix regions (Tab. 1) which was statistically significant in S2 in LH, S1 in RH and in ACC, after indomethacin. fMRI demonstrated hypothalamic activation in all TACs, supporting the hypothesis that there are central pathways which underlie the mechanism of these headaches. PH neuroimaging showed activation of the posterior part of the opposite hypothalamus and the abdominal part of the midbrain extending to the red nucleus and black matter during attacks [4]. Such activity was inhibited by the administration of indomethacin, which at the same time clinically suppressed attacks.

In several PET and fMRI studies, the opposite activation of the hypothalamus during a SUNH attack has been described [5, 6]. It seems that fMRI on TACs (CH, PH, SUNH, HC) points toward a complex neural network performance deficit rather than to a single locus of abnormality, even though it remains undisputed that the hypothalamus plays an important role in the pathophysiology of this group of disorders [7]. Headache-induced BOLD changes have also been reported in an atypical case of TAC [8]. The cerebral activation pattern was similar, but not identical, to those previously observed with activation in the hypothalamic grey matter.

This is the first report of such a headache presenting fMRI data in both painful and pain-free periods, showing the involvement of the cortical regions of the brain in this disorder. Oral therapy was successful in our patient, so no other treatment method, e.g. radiosurgery [9], was considered.

References

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