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Research paper
Published online: 2020-10-12
Submitted: 2020-04-15
Accepted: 2020-08-29
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Internal carotid and vertebral artery dissections — a comparison of clinical, radiological and prognostic characteristics

Justyna Kos, Michał Kos, Jacek Jaworski, Véronique Petit, Katarzyna Wojtal, Konrad Rejdak
DOI: 10.5603/PJNNS.a2020.0078
·
Pubmed: 33047785

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Ahead of print
Research paper
Published online: 2020-10-12
Submitted: 2020-04-15
Accepted: 2020-08-29

Abstract

Aim of study. To examine whether baseline characteristics, potential risk factors, clinical symptoms, radiological presentation, and long-term outcomes differ between internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD).

Clinical rationale for study. Cervical artery dissection (CeAD) is a major cause of cerebral ischaemia in young adults. Its clinical course is highly variable, resulting in challenges in making a proper diagnosis.

Methods. We performed a retrospective analysis of 31 patients (mean age 42.2 years) with CeAD (18 with ICAD, 13 with VAD) treated in our neurology department from 2008 to 2018. Appropriate imaging confirmed the diagnosis of CeAD.

Results. Patients with ICAD presented Horner syndrome significantly more often (44.4% vs 7.6%; p = 0.04). Patients with VAD more often had ischaemic events (ischaemic stroke, TIA or transient blindness) (84.6% vs 44.6%; p = 0.0032). Ischaemic stroke was more severe in patients with ICAD [(median NIHSS 6, interquartile range 4–12) vs VAD (median NIHSS 4, interquartile range 1.5–5.5), p = 0,03]. Occlusion occurred more often in patients with VAD (69.2% vs 22.2%; p = 0.013). Most patients had a favourable outcome (mRS 0–2).

Conclusions and clinical implications. In a series of patients with CeAD, we observed significant differences between VAD and ICAD in terms of clinical symptoms and radiological features.

Abstract

Aim of study. To examine whether baseline characteristics, potential risk factors, clinical symptoms, radiological presentation, and long-term outcomes differ between internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD).

Clinical rationale for study. Cervical artery dissection (CeAD) is a major cause of cerebral ischaemia in young adults. Its clinical course is highly variable, resulting in challenges in making a proper diagnosis.

Methods. We performed a retrospective analysis of 31 patients (mean age 42.2 years) with CeAD (18 with ICAD, 13 with VAD) treated in our neurology department from 2008 to 2018. Appropriate imaging confirmed the diagnosis of CeAD.

Results. Patients with ICAD presented Horner syndrome significantly more often (44.4% vs 7.6%; p = 0.04). Patients with VAD more often had ischaemic events (ischaemic stroke, TIA or transient blindness) (84.6% vs 44.6%; p = 0.0032). Ischaemic stroke was more severe in patients with ICAD [(median NIHSS 6, interquartile range 4–12) vs VAD (median NIHSS 4, interquartile range 1.5–5.5), p = 0,03]. Occlusion occurred more often in patients with VAD (69.2% vs 22.2%; p = 0.013). Most patients had a favourable outcome (mRS 0–2).

Conclusions and clinical implications. In a series of patients with CeAD, we observed significant differences between VAD and ICAD in terms of clinical symptoms and radiological features.

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Keywords

dissection, stroke, risk factor, carotid artery, vertebral artery

About this article
Title

Internal carotid and vertebral artery dissections — a comparison of clinical, radiological and prognostic characteristics

Journal

Neurologia i Neurochirurgia Polska

Issue

Ahead of print

Published online

2020-10-12

DOI

10.5603/PJNNS.a2020.0078

Pubmed

33047785

Keywords

dissection
stroke
risk factor
carotid artery
vertebral artery

Authors

Justyna Kos
Michał Kos
Jacek Jaworski
Véronique Petit
Katarzyna Wojtal
Konrad Rejdak

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