Vol 54, No 4 (2020)
Research paper
Published online: 2020-06-17
Submitted: 2019-10-31
Accepted: 2020-04-27
Get Citation

Safety and tolerability of therapeutic plasma exchange in autoimmune neurological diseases — a retrospective single-centre analysis

Agnieszka Gala-Błądzińska, Katarzyna Mazur, Adam Dębiec, Krzysztof Gargasz, Halina Bartosik-Psujek
DOI: 10.5603/PJNNS.a2020.0045
·
Pubmed: 32557528
·
Neurol Neurochir Pol 2020;54(4):344-349.

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Vol 54, No 4 (2020)
Research paper
Published online: 2020-06-17
Submitted: 2019-10-31
Accepted: 2020-04-27

Abstract

Clinical rationale for study. The sudden onset of autoimmune neurological diseases often threatens life. In such clinical situations, fast, effective and safe treatment is needed. Therapeutic plasma exchange (TPE) is an option in the treatment of autoimmune disorders.

Aim of study. The aim was to assess the tolerability and safety of membrane-based therapeutic plasma exchange (mTPE) in patients with autoimmune neurological diseases.

Materials and methods. A total of 410 TPE treatments were performed in 91 adult patients. The main reasons for performing TPE were: Guillain-Barre syndrome (39.56%), chronic inflammatory demyelinating polyradiculoneuropathy (20.88%), and myasthenia gravis (17.58%).

Results.
A total of 183 (44.6%) mTPE treatments were performed without complications. In 18 (19.8%) patients, there were no complications observed in any of the mTPE procedures (a total of 83 procedures). Serious and life-threatening complications occurred during four (0.97%) mTPEs. The most common abnormality in laboratory tests was hypocalcaemia. In patients with a fibrinogen c oncentration ≥ 2 .63 g /L, m easured before the second plasmapheresis, coagulation in the TPE filter was more f requently o bserved (p = 0 .04).

Conclusions and clinical implications.
Our study proves that the use of plasmapheresis conducted by filtration in the treatment of autoimmune neurological diseases is safe and well tolerated.

Abstract

Clinical rationale for study. The sudden onset of autoimmune neurological diseases often threatens life. In such clinical situations, fast, effective and safe treatment is needed. Therapeutic plasma exchange (TPE) is an option in the treatment of autoimmune disorders.

Aim of study. The aim was to assess the tolerability and safety of membrane-based therapeutic plasma exchange (mTPE) in patients with autoimmune neurological diseases.

Materials and methods. A total of 410 TPE treatments were performed in 91 adult patients. The main reasons for performing TPE were: Guillain-Barre syndrome (39.56%), chronic inflammatory demyelinating polyradiculoneuropathy (20.88%), and myasthenia gravis (17.58%).

Results.
A total of 183 (44.6%) mTPE treatments were performed without complications. In 18 (19.8%) patients, there were no complications observed in any of the mTPE procedures (a total of 83 procedures). Serious and life-threatening complications occurred during four (0.97%) mTPEs. The most common abnormality in laboratory tests was hypocalcaemia. In patients with a fibrinogen c oncentration ≥ 2 .63 g /L, m easured before the second plasmapheresis, coagulation in the TPE filter was more f requently o bserved (p = 0 .04).

Conclusions and clinical implications.
Our study proves that the use of plasmapheresis conducted by filtration in the treatment of autoimmune neurological diseases is safe and well tolerated.

Get Citation

Keywords

autoimmune neurological diseases, therapeutic plasma exchange, efficacy, side effects

About this article
Title

Safety and tolerability of therapeutic plasma exchange in autoimmune neurological diseases — a retrospective single-centre analysis

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 54, No 4 (2020)

Pages

344-349

Published online

2020-06-17

DOI

10.5603/PJNNS.a2020.0045

Pubmed

32557528

Bibliographic record

Neurol Neurochir Pol 2020;54(4):344-349.

Keywords

autoimmune neurological diseases
therapeutic plasma exchange
efficacy
side effects

Authors

Agnieszka Gala-Błądzińska
Katarzyna Mazur
Adam Dębiec
Krzysztof Gargasz
Halina Bartosik-Psujek

References (11)
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