open access
Vol 53, No 2 (2019)
Review articles
Submitted: 2019-01-22
Accepted: 2019-01-22
Published online: 2019-03-27
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Vitamin D as an immune modulator in multiple sclerosis
1, 1
Affiliations- Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
open access
Vol 53, No 2 (2019)
Review articles
Submitted: 2019-01-22
Accepted: 2019-01-22
Published online: 2019-03-27
Abstract
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system. The disease is characterised by inflammation with extensive immune infiltration, demyelination, axonal loss and damage of oligodendrocytes, presumably auto-immune in nature. The influence of environmental factors on the development and activity of MS has been known for a long time. Vitamin D and sun exposure are among the most important ones. Both serum vitamin D level and sun exposure independent of vitamin D production are correlated with epidemiological and clinical parameters of MS, and the impact of vitamin D on immune parameters has been clearly confirmed in experimental studies. Nevertheless, the impact on clinical aspects is inconclusive, especially when the influence of supplementation is assessed. In this work we review the state of knowledge regarding the effect of vitamin D on immune cells subsets in relation to experimental and clinical studies.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of the central nervous system. The disease is characterised by inflammation with extensive immune infiltration, demyelination, axonal loss and damage of oligodendrocytes, presumably auto-immune in nature. The influence of environmental factors on the development and activity of MS has been known for a long time. Vitamin D and sun exposure are among the most important ones. Both serum vitamin D level and sun exposure independent of vitamin D production are correlated with epidemiological and clinical parameters of MS, and the impact of vitamin D on immune parameters has been clearly confirmed in experimental studies. Nevertheless, the impact on clinical aspects is inconclusive, especially when the influence of supplementation is assessed. In this work we review the state of knowledge regarding the effect of vitamin D on immune cells subsets in relation to experimental and clinical studies.
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Keywords
multiple sclerosis, vitamin D, supplementation, T cells, B cells, dendritic cells, macrophages
About this articleTitle
Vitamin D as an immune modulator in multiple sclerosis
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
113-122
Published online
2019-03-27
Page views
4530
Article views/downloads
5266
DOI
Pubmed
Bibliographic record
Neurol Neurochir Pol 2019;53(2):113-122.
Keywords
multiple sclerosis
vitamin D
supplementation
T cells
B cells
dendritic cells
macrophages
Authors
Halina Bartosik-Psujek
Marek Psujek
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