open access
Vol 8, No 1 (2023)
Invited editorial
Published online: 2023-02-06
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Antiplatelet treatment for older patients with ACS — a challenging issue
12, 12
Affiliations- Department of Molecular Medicine, University of Pavia Medical School, Pavia, Italy
- Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
open access
Vol 8, No 1 (2023)
INVITED EDITORIALS
Published online: 2023-02-06
Abstract
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Abstract
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About this articleTitle
Antiplatelet treatment for older patients with ACS — a challenging issue
Journal
Issue
Article type
Invited editorial
Pages
1-4
Published online
2023-02-06
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339
DOI
Bibliographic record
Medical Research Journal 2023;8(1):1-4.
Authors
Stefano De Servi
Antonio Landi
References (20)- Morici N, Servi SDe, Luca LDe, et al. Management of acute coronary syndromes in older adults. European Heart Journal. 2021; 43(16): 1542–1553.
- Damluji AA, Forman DE, Wang TY, et al. American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health. Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association. Circulation. 2023; 147(3): e32–e62.
- Damluji AA, Chung SE, Xue QL, et al. Physical Frailty Phenotype and the Development of Geriatric Syndromes in Older Adults with Coronary Heart Disease. Am J Med. 2021; 134(5): 662–671.e1.
- Ibanez B, James S, Agewall S, et al. [2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation.]. Kardiol Pol. 2018; 76(2): 229–313.
- Savonitto S, Cavallini C, Petronio AS, et al. Italian Elderly ACS Trial Investigators. Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial. JACC Cardiovasc Interv. 2012; 5(9): 906–916.
- Tegn N, Eek C, Abdelnoor M, et al. After Eighty study investigators, After Eighty study investigators. Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial. Lancet. 2016; 387(10023): 1057–1065.
- Wiviott S, Braunwald E, McCabe C, et al. Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes. New England Journal of Medicine. 2007; 357(20): 2001–2015.
- Wallentin L, Becker RC, Budaj A, et al. PLATO Investigators. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009; 361(11): 1045–1057.
- De Servi S, Goedicke J, Schirmer A, et al. Clinical outcomes for prasugrel versus clopidogrel in patients with unstable angina or non-ST-elevation myocardial infarction: an analysis from the TRITON-TIMI 38 trial. Eur Heart J Acute Cardiovasc Care. 2014; 3(4): 363–372.
- Husted S, James S, Becker RC, et al. PLATO study group. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes. 2012; 5(5): 680–688.
- Gimbel M, Qaderdan K, Willemsen L, et al. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial. Lancet. 2020; 395(10233): 1374–1381.
- Savonitto S, Ferri L, Piatti L, et al. Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization. Circulation. 2018; 137(23): 2435–2445.
- Crimi G, Morici N, Ferrario M, et al. Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low-Dose Prasugrel or Clopidogrel. J Am Heart Assoc. 2019; 8(2): e010956.
- De Servi S, Crimi G, Calabrò P, et al. Relationship between diabetes, platelet reactivity, and the SYNTAX score to one-year clinical outcome in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. EuroIntervention. 2016; 12(3): 312–318.
- De Servi S, Landi A, Savonitto S. Antiplatelet Therapy in Elderly Patients with Acute Coronary Syndromes: the Clopidogrel Revenge: Possible Reasons for a Bright Comeback. Cardiovasc Drugs Ther. 2021; 35(2): 399–401.
- Collet JP, Thiele H, Barbato E, et al. Siontis GCM; ESC Scientific Document Group 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021; 42: 1289–1367.
- Urban P, Gregson J, Owen R, et al. Assessing the Risks of Bleeding vs Thrombotic Events in Patients at High Bleeding Risk After Coronary Stent Implantation: The ARC-High Bleeding Risk Trade-off Model. JAMA Cardiol. 2021; 6(4): 410–419.
- Valgimigli M, Smits PC, Frigoli E, et al. MASTER DAPT Investigators, MASTER DAPT Investigators. Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. N Engl J Med. 2021; 385(18): 1643–1655.
- Hong SJ, Kim JS, Hong SJ, et al. One-Month DAPT Investigators. 1-Month Dual-Antiplatelet Therapy Followed by Aspirin Monotherapy After Polymer-Free Drug-Coated Stent Implantation: One-Month DAPT Trial. JACC Cardiovasc Interv. 2021; 14(16): 1801–1811.
- De Servi S, Landi A, Savonitto S, et al. Tailoring oral antiplatelet therapy in acute coronary syndromes: from guidelines to clinical practice. J Cardiovasc Med (Hagerstown). 2023; 24(2): 77–86.