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Vol 7, No 3 (2022)
Original article
Published online: 2022-09-20
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Biochemical markers of oxidative stress in patients with inflammatory bowel diseases

Grażyna Mierzwa1, Jacek Budzyński1, Daria Kupczyk2, Beata Augustyńska3
·
Medical Research Journal 2022;7(3):234-241.
Affiliations
  1. Department of Vascular and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
  2. Department of Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
  3. Institute of Physical Education, Kazimierz Wielki University in Bydgoszcz, Poland

open access

Vol 7, No 3 (2022)
ORIGINAL ARTICLES
Published online: 2022-09-20

Abstract

Introduction: Inflammatory bowel disease (IBD) is a group of diseases of unexplained aetiology, characterized by periods of remissions and exacerbations. Reactive oxygen species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in the occurrence of IBD. The aim of the present study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease.

Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) from Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was the material for biochemical analysis: HT, GSH, GPXp, GPXRBC, GST, GR, SOD-1, MDA, NO2-/NO3- and CP.

Results: There were statistically significant differences in oxidative stress parameters observed between the study group and the control group, especially concerning HT, GSH, GPXRBC, GST, SOD-1, MDA and NO2-/NO3-.

Discussion: The assumption that increased activity of antioxidative compounds may constitute a defence against the influence of oxidative stress may be true. Their decreased activity may participate in lowering an organism’s abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies into targeted preventive strategies are needed.

Conclusions: Prooxidative factors play an essential role in the pathogenesis of IBD. Due to the still unknown etiopathology of IBD, research on imbalances between pro-oxidants and antioxidants should be continued in larger groups of patients.

Abstract

Introduction: Inflammatory bowel disease (IBD) is a group of diseases of unexplained aetiology, characterized by periods of remissions and exacerbations. Reactive oxygen species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in the occurrence of IBD. The aim of the present study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease.

Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) from Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was the material for biochemical analysis: HT, GSH, GPXp, GPXRBC, GST, GR, SOD-1, MDA, NO2-/NO3- and CP.

Results: There were statistically significant differences in oxidative stress parameters observed between the study group and the control group, especially concerning HT, GSH, GPXRBC, GST, SOD-1, MDA and NO2-/NO3-.

Discussion: The assumption that increased activity of antioxidative compounds may constitute a defence against the influence of oxidative stress may be true. Their decreased activity may participate in lowering an organism’s abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies into targeted preventive strategies are needed.

Conclusions: Prooxidative factors play an essential role in the pathogenesis of IBD. Due to the still unknown etiopathology of IBD, research on imbalances between pro-oxidants and antioxidants should be continued in larger groups of patients.

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Keywords

oxidative stress, antioxidative barrier, inflammatory bowel disease

About this article
Title

Biochemical markers of oxidative stress in patients with inflammatory bowel diseases

Journal

Medical Research Journal

Issue

Vol 7, No 3 (2022)

Article type

Original article

Pages

234-241

Published online

2022-09-20

Page views

3773

Article views/downloads

370

DOI

10.5603/MRJ.a2022.0044

Bibliographic record

Medical Research Journal 2022;7(3):234-241.

Keywords

oxidative stress
antioxidative barrier
inflammatory bowel disease

Authors

Grażyna Mierzwa
Jacek Budzyński
Daria Kupczyk
Beata Augustyńska

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