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Changes in the microbiota of the genital tract and intestines in patients with adenomyosis and infertility
, 1, 1, 1
Affiliations- State University „Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
open access
Abstract
Introduction: Inflammation of the genital tract caused by a bacterial infection can affect the frequency of occurrence of hyperproliferative formations of the uterus, which in turn can lead to infertility. Changes in the microbiota of the vagina and intestines contribute to the formation of critical problems for women’s reproductive health.
Material and methods: Microbiota composition was studied using microscopic and cultural bacteriological methods in genitalia and intestines in 64 women with adenomyosis and infertility and 30 healthy women.
Results: The obtained results indicate that the microbiota of the genital tract in patients with adenomyosis and infertility is characterized by a different frequency of pathological manifestations (bacterial vaginosis, vaginitis, intermediate type of microbiocenosis) and excessive proliferation of vaginosis-associated microorganisms. Associative forms of bacterial contamination of the genital tract are registered in sick women. The formation of pathological intestinal microbiota in patients is largely due to a violation of the ratio between potentially pathogenic and protective species of bacteria.
Conclusions: In women with adenomyosis and infertility, a pathological microbiota of the genital tract is formed, which is characterized by an increase in the structure of vaginal bacteria of representatives of pathogenic aerobic and vaginosis-associated microorganisms, a deficiency of lactobacilli. Intestinal microbiota in patients is characterized by the formation of multicomponent associations, which with a significant frequency contain conditionally pathogenic microorganisms.
Abstract
Introduction: Inflammation of the genital tract caused by a bacterial infection can affect the frequency of occurrence of hyperproliferative formations of the uterus, which in turn can lead to infertility. Changes in the microbiota of the vagina and intestines contribute to the formation of critical problems for women’s reproductive health.
Material and methods: Microbiota composition was studied using microscopic and cultural bacteriological methods in genitalia and intestines in 64 women with adenomyosis and infertility and 30 healthy women.
Results: The obtained results indicate that the microbiota of the genital tract in patients with adenomyosis and infertility is characterized by a different frequency of pathological manifestations (bacterial vaginosis, vaginitis, intermediate type of microbiocenosis) and excessive proliferation of vaginosis-associated microorganisms. Associative forms of bacterial contamination of the genital tract are registered in sick women. The formation of pathological intestinal microbiota in patients is largely due to a violation of the ratio between potentially pathogenic and protective species of bacteria.
Conclusions: In women with adenomyosis and infertility, a pathological microbiota of the genital tract is formed, which is characterized by an increase in the structure of vaginal bacteria of representatives of pathogenic aerobic and vaginosis-associated microorganisms, a deficiency of lactobacilli. Intestinal microbiota in patients is characterized by the formation of multicomponent associations, which with a significant frequency contain conditionally pathogenic microorganisms.
Keywords
vaginal microbiota, intestinal microbiota, adenomyosis, infertility
About this articleTitle
Changes in the microbiota of the genital tract and intestines in patients with adenomyosis and infertility
Journal
Issue
Article type
Original article
Pages
197-202
Published online
2022-08-04
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3914
Article views/downloads
643
DOI
Bibliographic record
Medical Research Journal 2022;7(3):197-202.
Keywords
vaginal microbiota
intestinal microbiota
adenomyosis
infertility
Authors
Inna Georgievna Ponomarova
Tamara Oleksandrivna Lisyana
Olha Vitalyivna Trokhymovych
Olha Ivanivna Matyashova
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