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Abscopal effect in solid tumors. Potential mechanisms, application of radioimmunotherapy, and a review of exemplary clinical cases
, 2, 1, 1, 1, 1
Affiliations- Nicolaus Copernicus University in Torun, Collegium Medicum, Bydgoszcz, Poland
- Collegium Medicum Nicolaus Copernicus University, Ph student
open access
Abstract
The abscopal effect, also known as extra-local, is a phenomenon in which local treatment of a neoplastic
lesion causes regression of metastatic lesions located at a considerable distance from it.
The mechanism of this phenomenon is still not fully understood, however, there are some assumptions
about its pathophysiology. In 2004, it was postulated for the first time that the immune system might be
responsible for anti-cancer activities in this mechanism. This study aims to present the phenomenon of
the abscopal effect, its probable mechanisms, to discuss the anti-tumor effect of radiotherapy combined
with immunotherapy, and to present clinical cases.
Abstract
The abscopal effect, also known as extra-local, is a phenomenon in which local treatment of a neoplastic
lesion causes regression of metastatic lesions located at a considerable distance from it.
The mechanism of this phenomenon is still not fully understood, however, there are some assumptions
about its pathophysiology. In 2004, it was postulated for the first time that the immune system might be
responsible for anti-cancer activities in this mechanism. This study aims to present the phenomenon of
the abscopal effect, its probable mechanisms, to discuss the anti-tumor effect of radiotherapy combined
with immunotherapy, and to present clinical cases.
Keywords
abscopal effect, solid tumors, mechanisms, clinical cases
About this articleTitle
Abscopal effect in solid tumors. Potential mechanisms, application of radioimmunotherapy, and a review of exemplary clinical cases
Journal
Issue
Article type
Review article
Pages
334-341
Published online
2021-11-24
Page views
6013
Article views/downloads
504
DOI
Bibliographic record
Medical Research Journal 2021;6(4):334-341.
Keywords
abscopal effect
solid tumors
mechanisms
clinical cases
Authors
Katarzyna Białczyk
Monika Schultz
Drota Łuszkiewicz
Jakub Lisiecki
Robert Szafkowski
Anna Kanigowska
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