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Increased plasma levels of hsa-miR-21-5p in patients with reduced left ventricle ejection fraction admitted urgently due to acute coronary syndrome
, 4, 4, 3, 1, 1, 4, 3, 1
Affiliations- Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland
- First Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland
- First Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland
- Laboratory of Centre for Preclinical Research, Department of Methodology, Medical University of Warsaw, Warsaw, Poland, Banacha 1b, 02-097 Warsaw, Poland
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Abstract
Myocardial ischemia that occurs during acute coronary syndrome (ACS) induces a cascade of pathophysiological processes which might lead to left ventricle dysfunction reflected by decreased left ventricular ejection fraction (LVEF) in echocardiographic examination. The enzymes regulating extracellular matrix (ECM) like matrix metalloproteinase 9 (MMP-9) also take part in this process. The MMP-9 activity is under control of a microRNA particle miR-21, which down-regulates its inhibitors. The study has shown, that in ACS population (n = 26) patients with LVEF < 50% presented increased miR-21 relative expression levels comparing to patients with LVEF ≥50% (3,33 vs 1,64; p = 0,015). Moreover, a significant negative correlation between LVEF and miR-21 in this group of patients has also been presented.
Abstract
Myocardial ischemia that occurs during acute coronary syndrome (ACS) induces a cascade of pathophysiological processes which might lead to left ventricle dysfunction reflected by decreased left ventricular ejection fraction (LVEF) in echocardiographic examination. The enzymes regulating extracellular matrix (ECM) like matrix metalloproteinase 9 (MMP-9) also take part in this process. The MMP-9 activity is under control of a microRNA particle miR-21, which down-regulates its inhibitors. The study has shown, that in ACS population (n = 26) patients with LVEF < 50% presented increased miR-21 relative expression levels comparing to patients with LVEF ≥50% (3,33 vs 1,64; p = 0,015). Moreover, a significant negative correlation between LVEF and miR-21 in this group of patients has also been presented.
Keywords
acute coronary syndrome; metalloproteinase; extracellular matrix; micro-RNA; myocardial ischemia; left ventricle ejection fraction
About this articleTitle
Increased plasma levels of hsa-miR-21-5p in patients with reduced left ventricle ejection fraction admitted urgently due to acute coronary syndrome
Journal
Issue
Article type
Original article
Pages
250-255
Published online
2020-12-10
Page views
486
Article views/downloads
561
DOI
Bibliographic record
Medical Research Journal 2020;5(4):250-255.
Keywords
acute coronary syndrome
metalloproteinase
extracellular matrix
micro-RNA
myocardial ischemia
left ventricle ejection fraction
Authors
Michał Krzysztof Kowara
Wiktor Paskal
Agata Gondek
Renata Główczyńska
Karolina Rybak
Maciej Kubik
Paweł Włodarski
Grzegorz Opolski
Agnieszka Cudnoch-Jędrzejewska
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