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Myonectin serum concentration changes after short-term physical activity among young, healthy people
Affiliations- Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Mickiewicza 2, 60-834 Poznan, Poland
- Cardiology Ward, John Paul II District Hospital in Trzcianka, 64-980 Trzcianka, Poland
- Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Szamarzewskiego str. 82/84, 60-569 Poznan, Poland
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Abstract
Background: Myonectin is a myokine secreted by skeletal muscles in response to physical activity (PhA)
in rodents. It was shown that myonectin may be positively associated with insulin resistance parameters.
The aim of the study was to evaluate changes in the concentration of myonectin after short-term PhA.
Methods: A total of 29 young, healthy volunteers, were included in the study. Each participant completed
a life-style questionnaire, underwent a physical examination with anthropometric measurement followed
by a treadmill test according to theBruce protocol. Blood samples were collected before and after PhA.
An ELISA Assay was used to investigate the myonectin serum level.
Results: The myonectin serum level did not change significantly after PhA (0.62[0.14-2.9] vs. 1.08[0.15-2.44] ng/ml; p=0.84). Before PhA the myonectin serum level differed significantly between men and women (respectively: 3.92[2.24-5.30] vs. 0.56[0.15-1.75] ng/ml; p=0.02). Before PhA it had a positive association with weight, BMI, serum creatinine and uremic acid (p < 0.05). The change in the level of myonectin serum after PhA had negative associations with weight, BMI, fasting insulin level and HOMA-IR (p < 0.05).
Conclusions: Myonectin serum concentration does not change after short-term physical activity among
young, healthy people. Changes in the myonectin serum level after short-term physical activity may be
associated with fasting insulin resistance.
Abstract
Background: Myonectin is a myokine secreted by skeletal muscles in response to physical activity (PhA)
in rodents. It was shown that myonectin may be positively associated with insulin resistance parameters.
The aim of the study was to evaluate changes in the concentration of myonectin after short-term PhA.
Methods: A total of 29 young, healthy volunteers, were included in the study. Each participant completed
a life-style questionnaire, underwent a physical examination with anthropometric measurement followed
by a treadmill test according to theBruce protocol. Blood samples were collected before and after PhA.
An ELISA Assay was used to investigate the myonectin serum level.
Results: The myonectin serum level did not change significantly after PhA (0.62[0.14-2.9] vs. 1.08[0.15-2.44] ng/ml; p=0.84). Before PhA the myonectin serum level differed significantly between men and women (respectively: 3.92[2.24-5.30] vs. 0.56[0.15-1.75] ng/ml; p=0.02). Before PhA it had a positive association with weight, BMI, serum creatinine and uremic acid (p < 0.05). The change in the level of myonectin serum after PhA had negative associations with weight, BMI, fasting insulin level and HOMA-IR (p < 0.05).
Conclusions: Myonectin serum concentration does not change after short-term physical activity among
young, healthy people. Changes in the myonectin serum level after short-term physical activity may be
associated with fasting insulin resistance.
Keywords
myonectin, physical, activity, insulin, resistance, treadmill, homa-ir
About this articleTitle
Myonectin serum concentration changes after short-term physical activity among young, healthy people
Journal
Issue
Article type
Original article
Pages
41-45
Published online
2019-01-24
Page views
1054
Article views/downloads
1072
DOI
Bibliographic record
Medical Research Journal 2019;4(1):41-45.
Keywords
myonectin
physical
activity
insulin
resistance
treadmill
homa-ir
Authors
Mikołaj Kamiński
Joanna Kippen
Anna Gomulska
Justyna Smyrak
Marcin Karolewski
Lena Bielawska
Ewa Wysocka
Maciej Cymerys
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