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Vol 4, No 1 (2019)
CASE REPORTS
Published online: 2018-12-19
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Biphosphonates-related osteonecrosis of the jaw

Katarzyna Białożyk-Mularska, Krzysztof Roszkowski
DOI: 10.5603/MRJ.a2018.0038
·
Medical Research Journal 2019;4(1):58-62.

open access

Vol 4, No 1 (2019)
CASE REPORTS
Published online: 2018-12-19

Abstract

The relationship between osteonecrosis of the jaw and bisphosphonate therapy has been described
recently. Although bisphosphonates have a long list of benefits in the treatment of patients with bone
metastases, an increasing number of reports describe the complication of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are synthetic analogues of pyrophosphate that inhibit
bone resorption. The aetiology of BRONJ is unclear. It starts as aseptic necrosis, with a surgical procedure
involving an interruption in the continuity of the oral mucosa as an obligatory precondition. Subsequently,
areas of osteonecrosis occur and detach from the surrounding areas of purulent inflammation or can be
removed surgically. Due to the limited treatment options, conservative treatment supported by antibiotic
and surgical therapy is used. This article describes a case of BRONJ.

Abstract

The relationship between osteonecrosis of the jaw and bisphosphonate therapy has been described
recently. Although bisphosphonates have a long list of benefits in the treatment of patients with bone
metastases, an increasing number of reports describe the complication of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are synthetic analogues of pyrophosphate that inhibit
bone resorption. The aetiology of BRONJ is unclear. It starts as aseptic necrosis, with a surgical procedure
involving an interruption in the continuity of the oral mucosa as an obligatory precondition. Subsequently,
areas of osteonecrosis occur and detach from the surrounding areas of purulent inflammation or can be
removed surgically. Due to the limited treatment options, conservative treatment supported by antibiotic
and surgical therapy is used. This article describes a case of BRONJ.

Get Citation

Keywords

bisphosphonate, osteonecrosis, jaws, osteoporosis

About this article
Title

Biphosphonates-related osteonecrosis of the jaw

Journal

Medical Research Journal

Issue

Vol 4, No 1 (2019)

Pages

58-62

Published online

2018-12-19

DOI

10.5603/MRJ.a2018.0038

Bibliographic record

Medical Research Journal 2019;4(1):58-62.

Keywords

bisphosphonate
osteonecrosis
jaws
osteoporosis

Authors

Katarzyna Białożyk-Mularska
Krzysztof Roszkowski

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