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RCAS1 and B7H4 antigens immunoreactivity in squamous cell carcinoma of palatine tonsils and cancer microenvironment
Affiliations- Uniwersytet Jagielloński Collegium Medicum Uniwersytecki Szpital Dziecięcy, Wielicka 265, 30-663 Kraków
- Centrum Onkologii w Bydgoszczy, Romanowskiej 2, 85-796 Bydgoszcz
- Department of Pathology, Jagiellonian University, Kraków, Poland
- Jagiellonian University Medical College, Faculty of Medicine, Kraków, Poland
- Department of Gynecological Oncology Lukaszczyk Oncological Center in Bydgoszcz, Poland
- Chair of Oncology, Radiotherapy and Gynecological Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland
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Abstract
B7-H4 protein has been demonstrated to be over-expressed by various types of cancer cells. The level
of expression of B7-H4 in these cancers is related to the type of cancer, its stage, and the number of
Treg cells, and correlates with patient survival and might be a new therapeutic target. The major role of
RCAS1 expression is to inhibit activated immune cells, such as T and B lymphocytes and NK cells, and
to induce their apoptosis. It has also been postulated that RCAS1 is involved in the remodelling of the
tumour microenvironment.
The aim of the present study has been to evaluate RCAS1- and B7-H4-antigen immunoreactivity in squamous
cell carcinoma of the palatine tonsils and in the cancer microenvironment. For our study, we recruited
30 patients with primary squamous cell carcinoma originating from the palatine tonsils.
Abstract
B7-H4 protein has been demonstrated to be over-expressed by various types of cancer cells. The level
of expression of B7-H4 in these cancers is related to the type of cancer, its stage, and the number of
Treg cells, and correlates with patient survival and might be a new therapeutic target. The major role of
RCAS1 expression is to inhibit activated immune cells, such as T and B lymphocytes and NK cells, and
to induce their apoptosis. It has also been postulated that RCAS1 is involved in the remodelling of the
tumour microenvironment.
The aim of the present study has been to evaluate RCAS1- and B7-H4-antigen immunoreactivity in squamous
cell carcinoma of the palatine tonsils and in the cancer microenvironment. For our study, we recruited
30 patients with primary squamous cell carcinoma originating from the palatine tonsils.
Keywords
B7H4, RCAS1, cancer microenvironment, tonsillar cancer
About this articleTitle
RCAS1 and B7H4 antigens immunoreactivity in squamous cell carcinoma of palatine tonsils and cancer microenvironment
Journal
Issue
Article type
Original article
Pages
134-141
Published online
2018-10-25
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876
Article views/downloads
778
DOI
Bibliographic record
Medical Research Journal 2018;3(3):134-141.
Keywords
B7H4
RCAS1
cancer microenvironment
tonsillar cancer
Authors
Magdalena Dutsch-Wicherek
Agata Lazar
Romana Tomaszewska
Kornelia Kliś
Konrad Dziobek
Łukasz Wicherek
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